In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/Copolymer Inclusion for Tissue Engineering Repaira
In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/Copolymer Inclusion for Tissue Engineering Repaira
复制标题
基于环糊精/共聚物包合物的原位电活性和抗氧化超分子水凝胶用于组织工程修复(a)
DOI：
10.1002/mabi.201300366
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发表时间：
2014-03-01
影响因子：
4.6
通讯作者：
Chen, Xuesi
中科院分区：
文献类型：
--
作者：
Cui, Haitao;Cui, Liguo;Chen, Xuesi
将四苯胺功能化共聚物与β-环糊精（-CD）水溶液混合，制备了可注射的电活性抗氧化水凝胶。共聚物溶液的UV-vis和CV显示出良好的电活性。同时也证明了共聚物的抗氧化能力。用WAXD、DSC和流变仪研究了体系的成胶机理和性能。包封的细胞在水凝胶中是高度活的，表明水凝胶具有优异的细胞相容性。皮下注射后，H&E染色研究表明材料的体内生物相容性可接受。此外，数据显示，可注射的电活性材料可以有效地促进封装细胞的电刺激的增殖，并阐述了其机制。这种可注射的电活性水凝胶将更接近地模拟天然细胞外基质，从而结合长期细胞存活的仿生环境和电信号以支持功能组织的产生。
The injectable electroactive and antioxidant hydrogels are prepared from mixing the tetraaniline functional copolymers and -cyclodextrin (-CD) aqueous solution. UV-vis and CV of the copolymer solution showed good electroactive properties. The antioxidant ability of the copolymer is also proved. The gelation mechanism and properties of the system are studied by WAXD, DSC, and rheometer. The encapsulated cells are highly viable in the hydrogels, suggesting that the hydrogels have excellent cytocompatibility. After subcutaneous injection, H&E staining study suggests acceptable biocompatibility of the materials in vivo. Moreover, data shows the injectable electroactive material can effectively accelerate the proliferation of encapsulated cells with electrical stimuli, and the mechanism is also elaborated. Such an injectable electroactive hydrogel would more closely mimic the native extracellular matrix, thereby combining a biomimetic environment of long-term cell survival and electrical signal to support the generation of functional tissue.