Expression of an uncoupling protein gene homolog in chickens
Expression of an uncoupling protein gene homolog in chickens
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DOI：
10.1016/s1095-6433(02)00113-7
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发表时间：
2002-10-01
影响因子：
2.3
通讯作者：
McMurtry, JP
中科院分区：
文献类型：
--
作者：
Evock-Clover, CM;Poch, SM;McMurtry, JP
一个禽解偶联蛋白（UCP）基因同源物最近从骨骼肌中测序，并提出了在鸡，鸭和蜂鸟的产热作用。由于哺乳动物UCP 2和UCP 3似乎也具有与能量和底物分配以及体重调节相关的功能，因此本研究的目的是进一步表征营养应激和/或瘦素施用条件下鸡UCP的特征。将3周龄的雄性鸡饥饿24或48 h，然后将每组中的一半再喂养另外24 h。在后续的实验中，鸡喂养或饥饿48小时或不瘦素管理。饥饿使骨骼肌UCP mRNA表达增加260%（P
An avian uncoupling protein (UCP) gene homolog was recently sequenced from skeletal muscle and was proposed to have a role in thermogenesis in chickens, ducks and hummingbirds. Since mammalian UCP 2 and UCP 3 also appear to have functions associated with energy and substrate partitioning and body weight regulation, the purpose of this study was to further characterize chicken UCP under conditions of nutritional stress and/or leptin administration. Male 3-week-old chickens were starved for 24 or 48 h and then half of each group was refed for an additional 24 h. In a follow-up experiment, chickens were fed or starved for 48 h with or without leptin administration. Feed deprivation increased UCP mRNA expression in skeletal muscle by up to 260% (P