Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
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DOI：
10.1002/anie.200390115
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Fenical, W
中科院分区：
文献类型：
--
作者：
Feling, RH;Buchanan, GO;Fenical, W
我们最近报道了一组新的专性海洋放线菌细菌的培养和系统发育特征，这种细菌广泛分布于海洋沉积物中。[1]类似的土壤来源的放线菌一直是自然产生的微生物抗生素的最重要来源，[2]因此，在海洋沉积物中发现一组主要的新细菌表明，海洋代表着一个被忽视的栖息地，从那里分离这些重要的微生物。鉴于从常见土壤放线菌中发现新的生物活性化合物的速度一直在下降，[3]专性海洋放线菌为结构多样化的次生代谢产物提供了一个新的资源。到目前为止，我们已经分离出2500多株属于这个新分类群的菌株，我们建议将这个新分类群命名为™Salinospora∫(正式的分类学描述正在进行中)。™Salinospora∫菌株，具有以前未描述的16SRRNA基因序列，已从五个不同的热带/亚热带海洋系统[1]和深至±1100米的深度中被发现，这表明它们代表了一个分布广泛且分类多样化的沉积物细菌群。所有的分离物都表现出对离子钠生长的专有需求，因此表明海洋适应程度很高。
We recently reported the cultivation and phylogenetic characterization of a new group of obligate marine actinomycete bacteria that is widely distributed in ocean sediments.[1] Analogous soil-derived actinomycetes have been the single most significant source of naturally occurring microbial antibiotics,[2] thus the discovery of a major new group of these bacteria in marine sediments suggests that the ocean represents an overlooked habitat from which to isolate these important microorganisms. Given that the rate of discovery of new biologically active compounds from common soil actinomycetes has been falling,[3] obligate marine actinomycetes represent a new resource for structurally diverse secondary metabolites.To date, we have isolated in excess of 2500strains belonging to this new taxon for which we have proposed the genus name™ Salinospora∫(a formal taxonomic description is in progress).™ Salinospora∫ strains, with previously undescribed 16S rRNA gene sequences, have been recovered from five distinct tropical/subtropical ocean systems [1] and from depths as great as À1100m, which indicates that they represent a widely distributed and taxonomically diverse group of sediment bacteria. All isolates display an obligate requirement of ionic sodium for growth, thus indicating a high level of marine adaptation.