Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.
Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.
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DOI：
10.1016/j.tibtech.2018.01.003
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发表时间：
2018-04
影响因子：
17.3
通讯作者：
G. Potjewyd;S. Moxon;Tao Wang;M. Domingos;N. Hooper
中科院分区：
文献类型：
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作者：
G. Potjewyd;S. Moxon;Tao Wang;M. Domingos;N. Hooper
神经血管功能障碍是中风和包括阿尔茨海默病在内的大多数神经退行性疾病发病机制的中心过程。多细胞神经血管单位（NVU）将神经，血管和细胞外基质（ECM）成分结合在一个重要的界面中，其正确的功能对维持大脑健康至关重要。组织工程现在提供了新的工具和见解，以促进我们对NVU功能的理解。在这里，我们回顾了如何使用新型生物材料来模拟ECM的机械和功能线索，再加上通过3D生物打印精确分层沉积NVU的不同细胞，正在彻底改变神经血管功能和功能障碍的研究。
Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is critical to maintain brain health. Tissue engineering is now offering new tools and insights to advance our understanding of NVU function. Here, we review how the use of novel biomaterials to mimic the mechanical and functional cues of the ECM, coupled with precisely layered deposition of the different cells of the NVU through 3D bioprinting, is revolutionising the study of neurovascular function and dysfunction.