In vivo association between low wall shear stress and plaque in subjects with asymmetrical carotid atherosclerosis
In vivo association between low wall shear stress and plaque in subjects with asymmetrical carotid atherosclerosis
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DOI：
10.1161/01.str.28.5.993
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发表时间：
1997-05-01
期刊：
影响因子：
8.3
通讯作者：
Pujia, A
中科院分区：
文献类型：
--
作者：
Gnasso, A;Irace, C;Pujia, A
背景和目的众所周知，动脉粥样硬化并不以相同的程度累及两侧颈动脉。病理学研究表明，病变发生在低壁切应力区域。本研究的目的是验证颈动脉粥样硬化不对称的程度在一项以人群为基础的研究，并评估是否壁切应力是较低的颈动脉粥样硬化病变比颈动脉无lesions.Methods参与者在心血管疾病预防运动（n=1166）进行了筛选颈动脉粥样硬化回声多普勒检查。其中23名受试者的一侧颈总动脉或球部存在斑块，而对侧颈动脉树无斑块，入选进行颈总动脉壁剪切应力测量。根据以下公式计算剪切应力：剪切应力=血液粘度×血流速度/内径。结果在1166例受试者中，400例（34%）颈动脉有斑块和/或狭窄。90例受试者的病变仅发生在右侧颈动脉，111例仅发生在左侧颈动脉，70例病变发生在两侧颈动脉，但严重程度不同，只有129例病变在两侧颈动脉相似。在23名测量壁面剪切应力的受试者中，峰值剪切应力分别为18.7+/-4.1和15.3+/-4.0 dynes.cm（-2）（平均值+/-SD）（P
Background and Purpose It is known that atherosclerosis does not involve both carotid arteries to the same extent. Pathological investigations have demonstrated that lesions develop in regions of low wall shear stress. The aims of the present study were to verify the degree of carotid atherosclerosis asymmetry in a population-based study and to evaluate whether wall shear stress is lower in carotids with atherosclerotic lesions than in carotids without lesions.Methods Participants in a cardiovascular disease prevention campaign (n=1166) were screened for carotid atherosclerosis by echo-Doppler examination. Of these, 23 subjects who pre -sented plaque in the common carotid or bulb of one side and no plaque in the contralateral carotid tree were enrolled for common carotid wall shear stress measurement. Shear stress was calculated according to the following formula: Shear Stress=Blood ViscosityxBlood Velocity/Internal Diameter.Results Of the 1166 subjects screened, 400 (34%) had plaque and/or stenosis in the carotids. Ninety subjects had lesions exclusively in the right carotid, 111 had lesions exclusively in the left, 70 had lesions in both carotids but with different degrees of severity, and only 129 had similar lesions in both carotids. In the 23 subjects in whom wall shear stress was measured, peak shear stress was 18.7+/-4.1 and 15.3+/-4.0 dynes.cm(-2) (mean+/-SD) (P