Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
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DOI：
10.1073/pnas.1531903100
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发表时间：
2003-07-22
影响因子：
11.1
通讯作者：
Glaser, R
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, JK;Preacher, KJ;Glaser, R
IL-6（一种促炎细胞因子）的过度产生与一系列年龄相关病症相关，包括心血管疾病、骨质疏松症、关节炎、2型糖尿病、某些癌症、牙周病、虚弱和功能衰退。为了描述经历慢性应激源的老年人6年内IL-6的变化模式，这项纵向社区研究评估了119名男性和女性中慢性应激与IL-6产生之间的关系，这些男性和女性为患有痴呆症的配偶和106名非照顾者提供服务，整个样本的平均年龄为70.58岁（SD = 8.03）。在进入纵向研究的这一部分时，28名照顾者的配偶已经死亡，另外119名配偶中有50名在本研究的6年期间死亡。在6年内测量IL-6水平和与IL-6相关的健康行为。照顾者的IL-6平均增加率是非照顾者的四倍。此外，即使在受损配偶死亡数年后，前照顾者的IL-6的平均年度变化与当前照顾者的变化也没有差异。在慢性健康问题、药物或健康相关行为方面没有系统性的组间差异，这些差异可能是照顾者IL-6斜率更陡的原因。这些数据提供了一种关键机制的证据，通过这种机制，慢性压力可能会通过过早老化免疫反应来加速许多与年龄有关的疾病的风险。
Overproduction of IL-6, a proinflammatory cytokine, is associated with a spectrum of age-related conditions including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. To describe the pattern of change in IL-6 over 6 years among older adults undergoing a chronic stressor, this longitudinal community study assessed the relationship between chronic stress and IL-6 production in 119 men and women who were caregiving for a spouse with dementia and 106 noncaregivers, with a mean age at study entry of 70.58 (SD = 8.03) for the full sample. On entry into this portion of the longitudinal study, 28 of the caregivers' spouses had already died, and an additional 50 of the 119 spouses died during the 6 years of this study. Levels of IL-6 and health behaviors associated with IL-6 were measured across 6 years. Caregivers' average rate of increase in IL-6 was about four times as large as that of noncaregivers. Moreover, the mean annual changes in IL-6 among former caregivers did not differ from that of current caregivers even several years after the death of the impaired spouse. There were no systematic group differences in chronic health problems, medications, or health-relevant behaviors that might have accounted for caregivers' steeper IL-6 slope. These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response.