4 DIFFERENT INTERLEUKIN-1 SPECIES SENSITIZE TO THE LETHAL ACTION OF TUMOR NECROSIS FACTOR
4 DIFFERENT INTERLEUKIN-1 SPECIES SENSITIZE TO THE LETHAL ACTION OF TUMOR NECROSIS FACTOR
复制标题
DOI：
10.1016/0006-291x(89)92146-3
复制
发表时间：
1989-08-30
影响因子：
3.1
通讯作者：
FIERS, W
中科院分区：
文献类型：
--
作者：
EVERAERDT, B;BROUCKAERT, P;FIERS, W
我们研究了肿瘤坏死因子（Tumor Necrosis Factor， TNF）对小鼠致死性休克的诱导作用，发现人和小鼠TNF对致死性休克的作用有显著差异，这种差异可以通过联合增敏剂消除。我们发现白细胞介素-1 （il -1）是一种天然致敏剂，使小鼠对人TNF和小鼠TNF一样敏感。这种il - 1活性被发现在人和小鼠il - 1- α中发挥相同的程度。摘要意思度量。也不同于用半乳糖胺获得的增敏效果，因为这些试剂具有加性作用。用吲哚美辛（一种环加氧酶抑制剂）预处理动物，对il - 1致敏小鼠提供了部分TNF致敏保护，而对半乳糖胺致敏小鼠则没有。
We studied the induction of lethal shock by Tumor Necrosis Factor (TNF) in mice and observed a remarkable difference between the effect of human and murine TNF, which could be eliminated by coadministration of sensitizing agents. We identified interleukin-1 (IL1) as a natural sensitizer, rendering mice as susceptible to human TNF as to murine TNF. This IL1 activity was found to be exerted to the same extent both by human and murine IL1-.alpha.or IL1-.beta., and was also different from the sensitization obtained with galactosamine, since these agents had an additive effect. Pretreatment of the animals with indomethacin, a cyclooxygenase inhibitor, provided partial protection against TNF lethality in IL1-sensitized but not in galactosamine-sensitized mice.