Association between C-reactive protein and insulin resistance in a Japanese population: The Minoh study
Association between C-reactive protein and insulin resistance in a Japanese population: The Minoh study
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DOI：
10.2169/internalmedicine.44.542
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发表时间：
2005-06-01
影响因子：
1.2
通讯作者：
Wada, M
中科院分区：
文献类型：
--
作者：
Nakanishi, N;Shiraishi, T;Wada, M
目的 探讨 C 反应蛋白 (CRP) 与胰岛素抵抗之间的关联。 材料和方法 本研究纳入 1,624 名年龄 40 至 69 岁的日本参与者（652 名男性和 972 名女性），他们非糖尿病患者、没有服用高血压或血脂异常药物、有心血管疾病史或 CRP 水平 > 10 mg/l。测量血清CRP水平、空腹血糖水平和空腹胰岛素水平，并使用胰岛素抵抗稳态模型评估（HOMA-IR）评估胰岛素抵抗程度。 CRP 的类别由以下三分位数定义：< 0.25 mg/l、0.25-0.59 mg/l 和 >= 0.60 mg/l。 结果 无论男性还是女性，CRP 水平升高均与空腹胰岛素水平、空腹血糖水平和 HOMA-IR 升高相关。尽管除年龄、吸烟和饮酒之外对体重指数进行调整削弱了 CRP 与空腹胰岛素、空腹血糖和 HOMA-IR 之间的关联，但无论男女，CRP 水平升高均与胰岛素水平和 HOMA-IR 升高相关。按 CRP 水平和肥胖进行的分层分析表明，无论男女，肥胖状态均与空腹胰岛素水平、空腹血糖水平和 HOMA-IR 升高相关，并且在相同 CRP 水平下，肥胖个体的空腹胰岛素水平、空腹血糖水平和 HOMA-IR 高于非肥胖个体。 结论 这些结果表明，亚临床炎症在日本人的胰岛素抵抗和葡萄糖不耐受中可能发挥作用，但这仅部分解释了肥胖与葡萄糖稳态受损之间的联系。
Objective To investigate the association between C-reactive protein (CRP) and insulin resistance.Materials and Methods This study included 1,624 Japanese participants (652 men and 972 women) aged 40 to 69 years who were non-diabetics or did not have medication for hypertension or dyslipidemia, a history of cardiovascular disease or CRP levels > 10 mg/l. Serum CRP level, fasting glucose level, and fasting insulin level were measured, and the degree of insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Categories of CRP were defined by the following tertiles: < 0.25 mg/l, 0.25-0.59 mg/l, and >= 0.60 mg/l.Results Elevated CRP levels were associated with increased fasting insulin levels, fasting glucose levels, and HOMA-IR in both men and women. Although the adjustment for body mass index in addition to age, cigarette smoking, and alcohol consumption attenuated the associations between CRP and fasting insulin, fasting glucose, and HOMA-IR, elevated CRP levels were associated with increased insulin levels and HOMA-IR in both sexes. Stratified analyses by CRP level and obesity showed that obesity status was associated with increased fasting insulin levels, fasting glucose levels, and HOMA-IR in both sexes and that fasting insulin levels, fasting glucose levels, and HOMA-IR were higher among obese individuals than among non-obese individuals at the same level of CRP.Conclusion These results suggest a possible role of subclinical inflammation in insulin resistance and glucose intolerance in Japanese, but it only partly explains the link between obesity and impaired glucose homeostasis.