Lipoprotein lipase and hepatic lipase activity after heparin administration in abetalipoproteinemia and hypobetalipoproteinemia.
Lipoprotein lipase and hepatic lipase activity after heparin administration in abetalipoproteinemia and hypobetalipoproteinemia.
复制标题
无β脂蛋白血症和低β脂蛋白血症肝素给药后脂蛋白脂肪酶和肝脂肪酶活性。
DOI：
10.1016/0026-0495(83)90199-3
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Alam,NA
中科院分区：
文献类型：
--
作者：
Illingworth,DR;Alam,SS;Alam,NA
本研究的目的是检查血浆中富含甘油三酯的脂蛋白（乳糜微粒和极低密度脂蛋白）的存在与否是否与肝素给药后脂蛋白脂肪酶或肝脂肪酶的酶活性变化有关。为了研究这一点，在服用肝素后测定了对照受试者、两名杂合性低β脂蛋白血症患者和三名表型无β脂蛋白血症患者的肝脂肪酶和脂蛋白脂肪酶活性。这两种酶在低β脂蛋白血症患者中表现出正常活性，但在无β脂蛋白血症患者中表现出持续降低的活性。静脉注射肝素15分钟后，这三名患者的血浆样本中肝脂肪酶活性分别为对照组的55%、87%和46%，而肝素注射后30分钟获得的血浆样本中的相应值分别为47%、70%和57%。注射肝素后15分钟获得的样本中，三名无β脂蛋白血症患者的脂蛋白脂肪酶活性分别为对照的46%、29%和34%，而30分钟后获得的值分别为对照的53%、64%和47%。我们得出的结论是，富含甘油三酯的脂蛋白的固有缺失（如无β脂蛋白血症中所发生的那样）与肝素给药后血浆中肝脂肪酶和脂蛋白脂肪酶的酶活性降低有关。
The purpose of this study was to examine whether and absence of triglyceride-rich lipoproteins (chylomicrons and very-low-density lipoproteins) in plasma is associated with any changes in the enzyme activity of lipoprotein lipase or hepatic lipase after heparin administration. To study this, the activities of hepatic lipase and lipoprotein lipase were determined in control subjects, in two patients with heterozygous hypobetalipoproteinemia, and in three patients with phenotypic abetalipoproteinemia after administration of heparin. Both enzymes showed normal activity in the patients with hypobetalipoproteinemia, but showed consistently reduced activity in the patients with abetalipoproteinemia. Hepatic lipase activity in plasma samples from these three patients obtained 15 minutes after intravenous injection of heparin was 55%, 87%, and 46% of that of the controls, whereas corresponding values in plasma samples obtained 30 minutes after heparin were 47%, 70%, and 57%, respectively. Lipoprotein lipase activity in the three patients with abetalipoproteinemia was 46%, 29%, and 34% of that of the controls in the samples obtained 15 minutes after heparin injection, whereas the values obtained after 30 minutes were 53%, 64%, and 47% of that of the controls. We conclude that an inherent absence of triglyceride-rich lipoproteins, as occurs in abetalipoproteinemia, is associated with reduced enzyme activity of both hepatic lipase and lipoprotein lipase in plasma after heparin administration.