Cholinergic Circuit Control of Postnatal Neurogenesis.
Cholinergic Circuit Control of Postnatal Neurogenesis.
复制标题
产后神经发生的胆碱能回路控制。
DOI：
10.1080/23262133.2015.1127310
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kuo,ChayT
中科院分区：
文献类型：
--
作者：
Asrican,Brent;Paez-Gonzalez,Patricia;Erb,Joshua;Kuo,ChayT
出生后/成年哺乳动物大脑中通过持续神经发生添加新神经元呈现出一种独特的神经系统可塑性形式。在胚胎发育期间，神经发生的精确时间和空间模式对于创建神经系统架构是必要的。在胚胎和出生后阶段之间类似，神经源性增殖由神经干细胞（NSC）调节，神经干细胞（NSC）是基于其局部微环境生态位的内在机制。在发育组装之后，仍然相对不清楚什么可能是维持出生后/成人大脑中神经元持续产生的关键驱动力。最近的实验证据表明，来自特定神经回路的模式化活动也可以直接支配出生后/成人的神经发生。在这里，我们回顾了实验结果，揭示胆碱能调制，以及如何模式的神经元活动和乙酰胆碱释放可能差异或协同激活下游信号在神经干细胞。高阶兴奋性和抑制性输入调节胆碱能神经元放电，其在神经发生控制的影响也被认为是。
New neuron addition via continued neurogenesis in the postnatal/adult mammalian brain presents a distinct form of nervous system plasticity. During embryonic development, precise temporal and spatial patterns of neurogenesis are necessary to create the nervous system architecture. Similar between embryonic and postnatal stages, neurogenic proliferation is regulated by neural stem cell (NSC)-intrinsic mechanisms layered upon cues from their local microenvironmental niche. Following developmental assembly, it remains relatively unclear what may be the key driving forces that sustain continued production of neurons in the postnatal/adult brain. Recent experimental evidence suggests that patterned activity from specific neural circuits can also directly govern postnatal/adult neurogenesis. Here, we review experimental findings that revealed cholinergic modulation, and how patterns of neuronal activity and acetylcholine release may differentially or synergistically activate downstream signaling in NSCs. Higher-order excitatory and inhibitory inputs regulating cholinergic neuron firing, and their implications in neurogenesis control are also considered.