Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults
Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults
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DOI：
10.1016/j.neuroimage.2013.04.069
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发表时间：
2013-10
期刊：
影响因子：
5.7
通讯作者：
I. Yakushev;G. Chételat;F. Fischer;B. Landeau;C. Bastin;A. Scheurich;Audrey Perrotin;M. Bahri;A. Drzezga;F. Eustache;M. Schreckenberger;A. Fellgiebel;E. Salmon
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文献类型：
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作者：
I. Yakushev;G. Chételat;F. Fischer;B. Landeau;C. Bastin;A. Scheurich;Audrey Perrotin;M. Bahri;A. Drzezga;F. Eustache;M. Schreckenberger;A. Fellgiebel;E. Salmon
功能连接的研究表明，默认模式网络（DMN）可能与认知功能有关。在这里，我们研究了主要DMN节点，后扣带回（PCC）和内侧前额叶皮层（MPFC）之间的代谢和结构连接，与正常的工作记忆（WM）。对35名健康青年（27.1± 5.1岁）的[18 F]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）数据进行独立成分分析。代谢连接，在PCC和MPFC的FDG摄取之间的相关性，进行了检查组（相对于中位数）低（n=18）和高（n=17）的数字跨度向后测试的性能作为口头WM的指标。此外，在一部分受试者中进行了基于PCC和MPFC节点作为路径点的纤维束成像。在DMN节点中的FDG摄取在高性能和低性能之间没有差异。然而，在低性能组中发现显著（p=0.01）较低的代谢连接。此外，与高性能相比，低性能表现出较低的左上级扣带束的密度。言语工作记忆表现与年轻健康成人DMN内的代谢和结构连接有关。用FDG-PET定量的代谢连接可能是某些认知功能正常变异的敏感标志物。
Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes, the posterior cingulate (PCC) and medial prefrontal cortex (MPFC), in relation to normal working memory (WM). DMN was captured using independent component analysis of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) data from 35 young healthy adults (27.1±5.1years). Metabolic connectivity, a correlation between FDG uptake in PCC and MPFC, was examined in groups of subjects with (relative to median) low (n=18) and high (n=17) performance on digit span backward test as an index of verbal WM. In addition, fiber tractography based on PCC and MPFC nodes as way points was performed in a subset of subjects. FDG uptake in the DMN nodes did not differ between high and low performers. However, significantly (p=0.01) lower metabolic connectivity was found in the group of low performers. Furthermore, as compared to high performers, low performers showed lower density of the left superior cingulate bundle. Verbal WM performance is related to metabolic and structural connectivity within the DMN in young healthy adults. Metabolic connectivity as quantified with FDG-PET might be a sensitive marker of the normal variability in some cognitive functions.