The regulatory power of glycans and their binding partners in immunity.
The regulatory power of glycans and their binding partners in immunity.
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DOI：
10.1016/j.it.2013.01.006
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发表时间：
2013-06
影响因子：
16.8
通讯作者：
Cobb BA
中科院分区：
文献类型：
--
作者：
Johnson JL;Jones MB;Ryan SO;Cobb BA
聚糖和聚糖结合蛋白对于正常运作的免疫系统至关重要。也许最著名的例子是表面蛋白的选择素家族，它主要存在于白细胞上，与感染或炎症部位附近的内皮聚糖结合，并能够外渗到组织中。然而，在过去的十年中，许多其他依赖于或对聚糖介导机制的变化敏感的免疫途径已被揭示。这些包括抗体功能、细胞凋亡、Th1 与 Th2 偏差、T 细胞受体信号传导和 MHC II 类抗原呈递。在这里，我们强调细胞表面和分泌糖蛋白上蛋白质糖基化的调节变化如何积极和消极地调节免疫反应。
Glycans and glycan-binding proteins are central to a properly functioning immune system. Perhaps the best known example of this is the selectin family of surface proteins that are primarily found on leukocytes, and which bind to endothelial glycans near sites of infection or inflammation and enable extravasation into tissues. In the past decade, however, a number of other immune pathways that are dependent on or sensitive to changes in glycan-mediated mechanisms have been revealed. These include antibody function, apoptosis, Th1 versus Th2 skewing, T cell receptor signaling, and MHC class II antigen-presentation. Here, we highlight how regulated changes in protein glycosylation both at the cell surface and on secreted glycoproteins can positively and negatively modulate the immune response.
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影响因子：
32.4
作者：
Demotte, Nathalie;Stroobant, Vincent;van der Bruggen, Pierre
通讯作者：
van der Bruggen, Pierre
影响因子：
4.3
作者：
Earl, Lesley A.;Bi, Shuguang;Baum, Linda G.
通讯作者：
Baum, Linda G.
DOI：
10.1073/pnas.0903497106
发表时间：
2009-08-25
影响因子：
11.1
作者：
Chen, Huan-Yuan;Fermin, Agnes;Liu, Fu-Tong
通讯作者：
Liu, Fu-Tong
影响因子：
4.8
作者：
Earl, Lesley A.;Bi, Shuguang;Baum, Linda G.
通讯作者：
Baum, Linda G.
DOI：
10.1073/pnas.0810163105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Anthony, Robert M.;Wermeling, Fredrik;Ravetch, Jeffrey V.
通讯作者：
Ravetch, Jeffrey V.