Rosemary (Rosmarinus officinalis L.) Leaf Extract Limits Weight Gain and Liver Steatosis in Mice Fed a High-Fat Diet
Rosemary (Rosmarinus officinalis L.) Leaf Extract Limits Weight Gain and Liver Steatosis in Mice Fed a High-Fat Diet
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DOI：
10.1055/s-0029-1240612
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发表时间：
2010-04-01
期刊：
影响因子：
2.7
通讯作者：
Darimont, Christian
中科院分区：
文献类型：
--
作者：
Harach, Taoufiq;Aprikian, Olivier;Darimont, Christian
本研究的目的是调查迷迭香 (Rosmarinus officinalis L.) 叶提取物 (RE) 对预防高脂肪饮食小鼠体重增加和相关代谢紊乱的影响。为此，以 20 或 200 毫克/千克体重 (BW) 的剂量向高脂肪饮食的小鼠施用 RE，持续 50 天。在研究期间监测体重，并在干预之前和结束时测量身体成分。通过腹膜内葡萄糖耐量试验（IPGTT）评估葡萄糖耐量，并在研究结束时测定肝脏和粪便的脂质含量。用 200mg/kg BW RE 治疗可显着降低体重和脂肪质量增加（分别为 -64% 和 -57%），并与粪便脂质排泄增加相关。正如体外所证明的，这种效应似乎与 RE 诱导的胰腺脂肪酶活性抑制有关。虽然葡萄糖耐量和空腹血糖不受 RE 治疗的影响，但 RE 治疗小鼠的肝甘油三酯水平降低了 39%。施用较低剂量的 RE（20 mg/kg BW）对所有测量参数均无效。总之，我们的结果表明，摄入 200 毫克/千克体重的 RE 可以限制高脂肪饮食引起的体重增加，并防止肥胖相关的肝脏脂肪变性。
The objective of this study was to investigate the effects of rosemary (Rosmarinus officinalis L.) leaf extract (RE) on the prevention of weight gain and associated metabolic disorders in mice fed a high-fat diet. For this purpose, RE was administered for 50 days at 20 or 200 mg/kg body weight (BW) to mice fed a high-fat diet. Body weight was monitored during the study and body composition was measured before and at the end of the intervention. Glucose tolerance, assessed by an intraperitoneal glucose tolerance test (IPGTT), and hepatic and faecal lipid contents were determined at the end of the study. Treatment with 200mg/kg BW of RE induced a significant reduction of weight and fat mass gain (-64% and -57%, respectively) associated with an increase of faecal lipid excretion. This effect appears to be related to the inhibition of pancreatic lipase activity induced by RE, as demonstrated in vitro. While glucose tolerance and fasting glycaemia were not affected by RE treatment, hepatic triglyceride levels were decreased by 39% in RE-treated mice. Administration of the lower dose of RE (20 mg/kg BW) was ineffective on all the parameters measured. In conclusion, our results demonstrate that consumption of 200 mg/kg BW of RE can limit weight gain induced by a high-fat diet and protect against obesity-related liver steatosis.