Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder
Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder
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DOI：
10.1016/s0920-9964(99)00123-1
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发表时间：
2000-05-05
影响因子：
4.5
通讯作者：
Siever, LJ
中科院分区：
文献类型：
--
作者：
Downhill, JE;Buchsbaum, MS;Siever, LJ
对27例精神分裂症患者、13例典型人格障碍（SPD）患者和30例健康志愿者的胼胝体矢状面磁共振图像进行了评估。获取高分辨率1.2 mm轴位SPGR图像并切除，使矢状面穿过前后连合并平行于纵裂。在每个脑的正中矢状面切片上追踪胼胝体和全脑，并将胼胝体分为30个前后区段。逐像素卡方和薄板样条分析用于评估组间形状差异。精神分裂症患者胼胝体前外侧和压部的大小均小于正常对照组。SPD患者胼胝体的宽度大于精神分裂症患者和正常对照组。胼胝体后部在正常人中最大，在SPD患者中较小，在精神分裂症患者中最小。形状分析与这些大小的比较是一致的，并建议向下弯曲的胼胝体在精神分裂症和SPD患者。SPD患者的胼胝体区域也比其他两组窄，就在胼胝体后部。精神分裂症患者胼胝体大小的减少与病程长短直接相关，这可能是一个渐进的过程。胼胝体大小和形状的患者对照差异与精神分裂症和SPD患者左右半球之间连接性降低的假设一致。(C)2000 Elsevier Science B.V.保留所有权利。
The size and shape of the corpus callosum were assessed on sagittal section magnetic resonance images in 27 patients with schizophrenia, 13 patients with schizotypal personality disorder (SPD), and 30 healthy volunteers. High-resolution 1.2 mm axial SPGR images were acquired and resectioned so that the sagittal plane passed through the anterior and posterior commissures and was parallel to the interhemispheric fissure. The corpus callosum and the whole brain were traced on midsagittal section slices of each brain, and the callosum was divided into 30 anteroposterior sectors. Pixel-by-pixel chi-square and thin-plate spline analyses were used to assess between-group shape differences. Size of the corpus callosum was smaller anteriorly in the genu of the corpus callosum and posteriorly in the splenium in schizophrenic patients than in normal controls. The genu of the corpus callosum was larger in SPD patients than in schizophrenic patients or normal controls. The posterior corpus callosum was largest in normal controls, smaller in SPD patients, and smallest in schizophrenic patients. Shape analysis was consistent with these size comparisons, and suggested a downward bowing of the corpus callosum in schizophrenic and SPD patients. SPD patients also had a region of the callosum just posterior to the genu that was narrower than in the other two groups. The decreases in corpus callosal size in schizophrenia varied directly with length of illness, perhaps indicative of a progressive process. The patient-control differences in callosal size and shape are consistent with a hypothesis of decreased connectivity between the left and the right hemispheres in schizophrenia and SPD. (C) 2000 Elsevier Science B.V. All rights reserved.