The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.
The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.
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DOI：
10.1016/j.neubiorev.2017.01.020
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发表时间：
2017-03
影响因子：
8.2
通讯作者：
Studenski SA
中科院分区：
文献类型：
--
作者：
Tian Q;Chastan N;Bair WN;Resnick SM;Ferrucci L;Studenski SA
虽然步态变异性可能反映了由于衰老或认知障碍（CI）引起的细微变化，但相关的大脑特征仍不清楚。我们总结了结构和功能的神经影像学研究结果与步态变异的老年人和不CI和痴呆。我们确定了17个合格的研究;所有的横断面;少数检查多个大脑区域。在老年人中，时间步态变异性与下肢协调和平衡重要的内侧区域的结构差异有关。时间和空间的步态变异性与海马和初级感觉运动皮层的结构和功能差异以及前扣带皮层、基底神经节、联合束和后丘脑辐射的结构差异相关。在CI或痴呆中，在初级运动皮层、海马、前额叶皮层和基底节中发现了一些关联。在老年人中，步态变异性可能与感觉运动整合和协调的重要区域有关。要了解步态变异与年龄和CI的神经基础，需要多个脑区的纵向研究。
While gait variability may reflect subtle changes due to aging or cognitive impairment (CI), associated brain characteristics remain unclear. We summarize structural and functional neuroimaging findings associated with gait variability in older adults with and without CI and dementia. We identified 17 eligible studies; all were cross-sectional; few examined multiple brain areas. In older adults, temporal gait variability was associated with structural differences in medial areas important for lower limb coordination and balance. Both temporal and spatial gait variability were associated with structural and functional differences in hippocampus and primary sensorimotor cortex and structural differences in anterior cingulate cortex, basal ganglia, association tracts, and posterior thalamic radiation. In CI or dementia, some associations were found in primary motor cortex, hippocampus, prefrontal cortex and basal ganglia. In older adults, gait variability may be associated with areas important for sensorimotor integration and coordination. To comprehend the neural basis of gait variability with aging and CI, longitudinal studies of multiple brain areas are needed.