Habitual Physical Activity Measured by Accelerometer and Survival in Maintenance Hemodialysis Patients
Habitual Physical Activity Measured by Accelerometer and Survival in Maintenance Hemodialysis Patients
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用加速度计测量维持性血液透析患者的习惯性体力活动量与存活率
DOI：
10.2215/cjn.03660412
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发表时间：
2012-12-01
影响因子：
9.8
通讯作者：
Takahira, Naonobu
中科院分区：
文献类型：
--
作者：
Matsuzawa, Ryota;Matsunaga, Atsuhiko;Takahira, Naonobu
背景与目的：血液透析患者死亡率与体力活动之间的关系，基于自我报告问卷，以前已有报道。然而，由于自我报告是一种主观评估，评估真实的身体活动是困难的。本研究调查了习惯性体力活动对临床稳定和充分透析患者队列的7年生存率的预后意义。在相模纯观诊所（日本）的血液透析中心接受每周3次维持性血液透析的202名日本门诊患者从2002年10月至2012年2月，随访长达7年。在进入研究时使用加速度计评估身体活动，并表示为患者在非透析日进行身体活动的时间。考克斯比例风险回归用于评估的贡献，习惯性体力活动的全因mortals.Results患者的中位年龄为64（25日，75日，57，72）岁，52.0%的患者是女性，中位时间为40.0（25日，75日，16.8，119.3）个月的血液透析基线。在平均45个月的随访中，34名患者死亡。多变量分析显示，体力活动每增加10 min/d，全因死亡率的风险比为0.78（95%可信区间，0.66-0.92; P=0.002）。结论维持性血液透析患者进行习惯性体力活动与死亡风险降低有关。Clin J Am Soc Nephrol 7：2010-2016，2012. doi：10.2215/CJN.03660412
Background and objectives The association between mortality and physical activity based on self-report questionnaire in hemodialysis patients has been reported previously. However, because self-report is a subjective assessment, evaluating true physical activity is difficult. This study investigated the prognostic significance of habitual physical activity on 7-year survival in a cohort of clinically stable and adequately dialyzed patients.Design, setting, participants, & measurements A total of 202 Japanese outpatients who were undergoing maintenance hemoclialysis three times per week at the hemodialysis center of Sagami Junkanki Clinic (Japan) from October 2002 to February 2012 were followed for up to 7 years. Physical activity was evaluated using an accelerometer at study entry and is expressed as the amount of time a patient engaged in physical activity on nondialysis days. Cox proportional hazard regression was used to assess the contribution of habitual physical activity to all-cause mortality.Results The median patient age was 64 (25th, 75th percentiles, 57, 72) years, 52.0% of the patients were women, and the median time on hemodialysis was 40.0 (25th, 75th percentiles, 16.8, 119.3) months at baseline. During a median follow-up of 45 months, 34 patients died. On multivariable analysis, the hazard ratio for all-cause mortality per 10 min/d increase in physical activity was 0.78 (95% confidence interval, 0.66-0.92; P=0.002).Conclusions Engaging in habitual physical activity among outpatients undergoing maintenance hemodialysis was associated with decreased mortality risk. Clin J Am Soc Nephrol 7: 2010-2016, 2012. doi: 10.2215/CJN.03660412