RESPONSES OF NEURONS IN THE PRIMATE TASTE CORTEX TO GLUTAMATE
RESPONSES OF NEURONS IN THE PRIMATE TASTE CORTEX TO GLUTAMATE
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DOI：
10.1016/0031-9384(91)90210-f
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发表时间：
1991-05-01
影响因子：
2.9
通讯作者：
ROLLS, ET
中科院分区：
文献类型：
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作者：
BAYLIS, LL;ROLLS, ET
为了研究灵长类动物体内谷氨酸的神经编码，在猕猴初级味觉皮质和毗邻的眶前皮质味觉区域的190个味觉反应神经元上进行了记录。发现单个神经元对谷氨酸(鲜味)的反应最好，就像其他细胞对葡萄糖(甜的)、氯化钠(咸的)、盐酸(酸的)和奎宁(苦的)反应最好一样。在整个神经元群体中，谷氨酸的反应性与氯化钠的反应性相关性较差，因此谷氨酸的表达与氯化钠的表达明显不同。此外，通过多维标度和聚类分析表明，谷氨酸的表示与其他四种口味的表示大致相同。此外，研究还发现，谷氨酸与其他四种刺激物葡萄糖、氯化钠、盐酸和奎宁一样，在平均诱发神经活动和对谷氨酸反应最好的细胞数量方面也有很好的表现。结果表明，在灵长类味觉皮层区域，产生鲜味的谷氨酸与葡萄糖(甜)、氯化钠(咸)、盐酸(酸)和奎宁(酸)产生的味道大致相同。
In order to investigate the neural encoding of glutamate in the primate, recordings were made from 190 taste responsive neurons in the primary taste cortex and adjoining orbitofrontal cortex taste area in macaques. Single neurons were found that were tuned to respond best to glutamate (umami taste), just as other cells were found with best responses to glucose (sweet), sodium chloride (salty), HCl (sour), and quinine HCl (bitter). Across the population of neurons, the responsiveness to glutamate was poorly correlated with the responsiveness to NaCl, so that the representation of glutamate was clearly different from that of NaCl. Further, the representation of glutamate was shown to be approximately as different from each of the other four tastants as they are from each other, as shown by multidimensional scaling and cluster analysis. Moreover, it was found that glutamate is approximately as well represented in terms of mean evoked neural activity and the number of cells with best responses to it as the other four stimuli, glucose, NaCl, HCl and quinine. It is concluded that in primate taste cortical areas, glutamate, which produces umami taste in humans, is approximately as well represented as are the tastes produced by: glucose (sweet), NaCl (salty), HCl (sour) and quinine HCl (sour).