BRUGIA-PAHANGI IN THE BALB/C MOUSE - A MODEL FOR TESTING FILARICIDAL COMPOUNDS
BRUGIA-PAHANGI IN THE BALB/C MOUSE - A MODEL FOR TESTING FILARICIDAL COMPOUNDS
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DOI：
10.1017/s0022149x00025657
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发表时间：
1985-01-01
影响因子：
1.6
通讯作者：
SMITH, G
中科院分区：
文献类型：
--
作者：
DEVANEY, E;HOWELLS, RE;SMITH, G
The BALB/C mouse infected with B. pahangi has been evaluated as a model for the selection of filaricidal compounds with activity against immature worms. Mice were infected by the i.p. inoculation of 50 infective larvae and candidate compounds were administered by the i.p., s.c. or oral route once daily from day 4 to day 8 postinfection. Animals were examined on days 29 to 32 postinfection. Variation in the larval recoveries from undrugged mice within and between experimental groups limited the value of drug assessments based upon percentage worm recoveries. The infection rate of undrugged mice was 85% overall, range 60 to 100%. Using the infection rate of drugged vs. undrugged animals as the criterion of activity the test has been evaluated with a series of standard nematicidal compounds.. Levamisole and the benzimidazole carbamates, mebendazole, flubendazole and fenbendazole given i.p. at 10 mg/kg daily were active in this screen whilst DEC [diethylcarbamazine citrate], DEC-N-oxide [diethylcarbamazine N-oxide hydrochloride], ivermectin, amoscanate, metrifonate and suramin were inactive at the dosages tested. No retardation of growth or morphological abnormalities were observed in worms from the drugged mice.
