Mathematical description of drug movement into tumor with EPR effect and estimation of its configuration for DDS
Mathematical description of drug movement into tumor with EPR effect and estimation of its configuration for DDS
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DOI：
10.1016/j.colsurfb.2009.08.013
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发表时间：
2010-01-01
影响因子：
5.8
通讯作者：
Ohya, Masanori
中科院分区：
文献类型：
--
作者：
Hara, Toshihide;Iriyama, Satoshi;Ohya, Masanori
药物输送系统（Drug Delivery System，DDS）是一种有效的抗肿瘤药物，可减少药物的副作用和有效剂量。（药物）在现阶段是凭经验决定的，这将涉及到应该给药多少的问题。考虑到肿瘤组织的一种称为EPR效应的特殊反应，我们试图用数学的方法来描述应用数学和物理学中的几种技术，研究药物在血管中的动力学在本文中，我们估计了在不同条件下对肿瘤治疗最有效的药物的配置。结果，该模型及其模拟将有助于设计纳米级药物（C）2009 Elsevier B.V.保留所有权利
It is known that Drug Delivery System (DDS) is useful to remedy against tumors for the reduction of side effects and the effective dosage However the shape, in particular, the size of drug (medicine) is empirically decided in the present stage, which will be related to a question how much medicine should be dosed Taking a particular reaction of tumor tissues called the EPR effect into consideration, we try to mathematically describe the behavior (dynamics) of drug in blood vessel by applying several techniques used in mathematics and physics In this paper, we estimate the configuration of drug which is most effective to remedy for tumors under various conditions As a result, this model and its simulation will be useful to design the drug in nano-level (C) 2009 Elsevier B.V. All rights reserved