Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram
Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram
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DOI：
10.1017/s0952523808080474
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发表时间：
2008-05-01
影响因子：
1.9
通讯作者：
Neitz, Jay
中科院分区：
文献类型：
--
作者：
Kuchenbecker, James A.;Sahay, Manisha;Neitz, Jay
用自制的宽视野彩色多焦视网膜电图仪测定视网膜对红光和绿色光的相对敏感度的地形分布。在外周中，与绿色光相比，对红光的相对敏感性增加，这与观察到的与中（M）波长敏感性视蛋白mRNA相比，长（L）波长敏感性视蛋白mRNA的相对量增加相关。这些结果提供了电生理学证据，即在人类视网膜的远周边中，L视锥与M视锥的比率显著增加。视锥比例的中央到远周边的均匀性对于理解确定视锥为L或M的身份的发育机制以及理解周边视网膜中的色觉电路具有意义。
The topographical distribution of relative sensitivity to red and green lights across the retina was assayed using a custom-made wide-field color multifocal electroretinogram apparatus. There were increases in the relative sensitivity to red compared to green light in the periphery that correlate with observed increases in the relative amount of long (L) compared to middle (M) wavelength sensitive opsin mRNA. These results provide electrophysiological evidence that there is a dramatic increase in the ratio of L to M cones in the far periphery of the human retina. The central to far peripheral homogeneity in cone proportions has implications for understanding the developmental mechanisms that determine the identity of a cone as L or M and for understanding the circuitry for color vision in the peripheral retina.