Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study
Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study
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DOI：
10.1016/j.mri.2008.05.014
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Jagannathan, Naranamangalam R.
中科院分区：
文献类型：
--
作者：
Balasubramanian, Krithika;Kumar, Sandeep;Jagannathan, Naranamangalam R.
应用体外高分辨质子磁共振波谱技术，对31例溃疡性结肠炎(UC)和26例克罗恩病(CD)患者及26例正常结肠黏膜的代谢进行了研究。31例UC患者中，活动期20例，缓解期1例。26例CD患者中，20例处于活动期，6例处于缓解期。在结肠粘膜的高氯酸提取物中明确指定了29种代谢物。活动期UC和CD显著低于活动期(P
Metabolism of the colonic mucosa of patients with ulcerative colitis (UC; n=31) and Crohn's disease (CD; n=26) and normal mucosa (control, n=26) was investigated using in vitro high-resolution proton magnetic resonance spectroscopy. Of the 31 UC patients, 20 were in the active phase and I I were in the remission phase of the disease. Out of 26 CD patients, 20 were in the active phase, while 6 were in the remission phase of the disease. Twenty-nine metabolites were assigned unambiguously in the perchloric acid extract of colonic mucosa. In the active phase of UC and CD, significantly lower (P