A new antibacterial dioxopiperazine alkaloid related to gliotoxin from a marine isolate of the fungus Pseudallescheria
A new antibacterial dioxopiperazine alkaloid related to gliotoxin from a marine isolate of the fungus Pseudallescheria
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DOI：
10.1038/ja.2006.35
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Son, Byeng Wha
中科院分区：
文献类型：
--
作者：
Li, Xifeng;Kim, Se-Kwon;Son, Byeng Wha
一种新型抗菌二氧代哌嗪、脱羟基双脱硫双（甲硫基）胶霉毒素 (1) 以及之前描述的双脱硫双（甲硫基）胶霉毒素 (2) 和胶霉毒素 (3)，已从海洋衍生真菌 Pseudallescheria 属的发酵液中分离出来。根据NMR和CD实验确定了新化合物的结构和绝对立体化学。与3相似的化合物1对耐甲氧西林和多重耐药金黄色葡萄球菌表现出有效的抗菌活性，MIC值分别为31.2、31.2和1.0μg/ml。化合物3还对1,1-二苯基-2-三硝基苯肼(DPPH)表现出显着的自由基清除活性，IC50值为5.2μM。
A new antibacterial dioxopiperazine, dehydroxybisdethiobis(methylthio)gliotoxin (1), and the previously described bisdethiobis(methylthio)gliotoxin (2) and gliotoxin (3), have been isolated from the broth of a marine-derived fungus of the genus Pseudallescheria. The structure and absolute stereochemistry of the new compound was assigned on the basis of NMR and CD experiments. Compounds 1 similar to 3 exhibit potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus with MIC values of 31.2, 31.2, and 1.0 mu g/ml, respectively. Compound 3 also exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 value of 5.2 mu M.