Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation
Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation
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DOI：
10.1007/s12185-018-2442-2
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发表时间：
2018-07-01
影响因子：
2.1
通讯作者：
Adachi, Souichi
中科院分区：
文献类型：
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作者：
Kawaguchi, Koji;Umeda, Katsutsugu;Adachi, Souichi
粘膜相关的不变性T细胞（MAIT）和不变性自然杀伤T细胞（iNKT）是具有先天样特性的T细胞亚群。我们研究了造血干细胞移植（HSCT）后MAIT和iNKT细胞恢复对京都大学医院接受同种异体造血干细胞移植的69例患者临床结果的影响。多因素分析发现，MAIT细胞的绝对数量（造血干细胞移植后第60天< 0.48/ μ L）是骨髓移植患者发生I-IV级和II-IV级急性移植物抗宿主病（aGVHD）的唯一独立危险因素；hsct后的iNKT细胞恢复与aGVHD的发生没有相关性。MAIT（高）（>= 0.48/ μ L）组的15例患者中有6例发生了aGVHD，其中5例在移植后的前30天内发生。相比之下，MAIT（低）（< 0.48/ μ L）组的15例患者中有13例在HSCT后第30天发生aGVHD。MAIT（低）组的总生存期略短于MAIT（高）组。因此，hsct后MAIT细胞的恢复与延迟性aGVHD的发展和hsct后的结果密切相关，这表明它可以用于识别需要更长时间和/或更强的GVHD预防的患者亚群。
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) cells are T cell subpopulations that possess innate-like properties. We examined the impact of post-hematopoietic stem cell transplantation (HSCT) MAIT and iNKT cell recovery on the clinical outcomes of 69 patients who underwent allogeneic HSCT at Kyoto University Hospital. Multivariate analyses identified the absolute number of MAIT cells (< 0.48/mu L on day 60 post-HSCT) as the sole independent risk factor for grade I-IV and grade II-IV acute graft-versus-host disease (aGVHD) among patients who underwent bone marrow transplantation; no correlation was observed between post-HSCT iNKT cell recovery and the development of aGVHD. Six of the 15 patients in the MAIT(high) (>= 0.48/mu L) group developed aGVHD, five within the first 30 days post HSCT. In contrast, 13 of the 15 patients in the MAIT(low) (< 0.48/mu L) group developed aGVHD, seven after day 30 post HSCT. The overall survival of the MAIT(low) group was slightly shorter than that of the MAIT(high) group. Thus, the post-HSCT recovery of MAIT cells is closely related to the development of delayed onset aGVHD and the outcome of post-HSCT, suggesting its utility for identifying a subset of patients that requires more prolonged and/or intense GVHD prophylaxis.