Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy: clinical prototype.
Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy: clinical prototype.
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使用激光扫描和荧光光谱法对儿童早期龋齿进行三模式检测：临床原型。
DOI：
10.1117/1.jbo.18.11.111412
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发表时间：
2013
影响因子：
3.5
通讯作者：
Seibel,EricJ
中科院分区：
文献类型：
--
作者：
Zhang,Liang;Kim,AmyS;Ridge,JeremyS;Nelson,LeonardY;Berg,JoelH;Seibel,EricJ
目前需要一种安全有效的方法来检测和诊断儿童早期龋齿。研制了一种活体诊断龋病脱矿的多模式光学临床样机。该设备可以通过使用405 nm激光作为照明源获得高分辨率和高对比度的表面图像，以及获得自发荧光和细菌荧光图像，从而快速成像和筛选任何脱矿牙釉质的迹象。当可疑的脱矿区域被定位时，该设备还使用405 nm和532 nm激光激发执行双重激光荧光光谱。计算两种激发激光的自体荧光比率，并用于定量诊断牙釉质健康。该装置在5名活体患者以及28颗临床诊断为龋损的拔除牙齿上进行了测试。该设备能够提供详细的图像，突出显示临床医生识别的病变。从拔除的牙齿中获得的自体荧光光谱比率成功地定量区分了声音牙釉质和脱矿牙釉质。
There is currently a need for a safe and effective way to detect and diagnose early stages of childhood caries. A multimodal optical clinical prototype for diagnosing caries demineralizationin vivohas been developed. The device can be used to quickly image and screen for any signs of demineralized enamel by obtaining high-resolution and high-contrast surface images using a 405-nm laser as the illumination source, as well as obtaining autofluorescence and bacterial fluorescence images. When a suspicious region of demineralization is located, the device also performs dual laser fluorescence spectroscopy using 405- and 532-nm laser excitation. An autofluorescence ratio of the two excitation lasers is computed and used to quantitatively diagnose enamel health. The device was tested on five patientsin vivoas well as on 28 extracted teeth with clinically diagnosed carious lesions. The device was able to provide detailed images that highlighted the lesions identified by the clinicians. The autofluorescence spectroscopic ratios obtained from the extracted teeth successfully quantitatively discriminated between sound and demineralized enamel.