RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype.
RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype.
复制标题
DOI：
10.1016/j.vaccine.2018.01.069
复制
发表时间：
2018-03-14
期刊：
影响因子：
5.5
通讯作者：
Ockenhouse CF
中科院分区：
文献类型：
--
作者：
Nielsen CM;Vekemans J;Lievens M;Kester KE;Regules JA;Ockenhouse CF
虽然RTS，S仍然是最先进的疟疾疫苗，但影响个体或群体之间疫苗免疫原性或效力差异的因素仍然缺乏特征。免疫原性遗传决定因素的分析以前受到个体试验相对较小样本量的限制。在这里，我们结合了6个II期RTS，S试验的数据，并使用多变量逻辑或线性回归评估HLA等位基因组与RTS，S介导的控制人疟疾感染（CHMI）保护之间的关系。我们观察到三个等位基因组（HLA-A∗01，HLA-B∗08和HLA-DRB1∗15/∗16）与保护之间存在显着关联，而另外三个等位基因组（HLA-A∗03，HLA-B∗53和HLA-DRB1∗07）与缺乏保护显着相关。值得注意的是，这些“保护性”等位基因群在撒哈拉以南非洲人群中的流行率被认为低于进行II期试验的英国或美国。综上所述，本文的分析表明HLA基因型可能影响RTS， s介导的疟疾感染保护作用。
Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenicity have previously been restricted by relatively small sample sizes from individual trials. Here we combine data from six Phase II RTS,S trials and evaluate the relationship between HLA allele groups and RTS,S-mediated protection in controlled human malaria infections (CHMI), using multivariate logistic or linear regression. We observed significant associations between three allele groups (HLA-A∗01, HLA-B∗08, and HLA-DRB1∗15/∗16) and protection, while another three allele groups (HLA-A∗03, HLA-B∗53, and HLA-DRB1∗07) were significantly associated with lack of protection. It is noteworthy that these ‘protective’ allele groups are thought to be at a lower prevalence in sub-Saharan African populations than in the UK or USA where these Phase II trials occurred. Taken together, the analyses presented here give an indication that HLA genotype may influence RTS,S-mediated protective efficacy against malaria infection.
登录
查看更多内容
DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
影响因子：
3.1
作者：
Ovsyannikova, Inna G.;Pankratz, V. Shane;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
5.3
作者：
Wu, Tzu-Wei;Chu, Chen-Chung;Wang, Li-Yu
通讯作者：
Wang, Li-Yu
影响因子：
6.4
作者：
Kester, Kent E.;Cummings, James F.;Heppner, D. Gray, Jr.
通讯作者：
Heppner, D. Gray, Jr.
影响因子：
5.5
作者：
Kester, Kent E.;Cummings, James F.;Heppner, D. Gray, Jr.
通讯作者：
Heppner, D. Gray, Jr.