Nickel-catalyzed amination of aryl carbamates and sequential site-selective cross-couplings
Nickel-catalyzed amination of aryl carbamates and sequential site-selective cross-couplings
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DOI：
10.1039/c1sc00230a
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发表时间：
2011-01-01
期刊：
影响因子：
8.4
通讯作者：
Garg, Neil K.
中科院分区：
文献类型：
--
作者：
Mesganaw, Tehetena;Silberstein, Amanda L.;Garg, Neil K.
我们报道了使用镍催化的氨基甲酸芳基酯的胺化。该方法对于偶联伙伴而言范围广泛，并以合成有用的产率提供胺化产物。计算研究提供了这种转化的完整催化循环，并表明还原消除是决定速率的步骤。鉴于氨基甲酸酯易于制备、稳定、对催化呈惰性且可用于芳烃官能化，因此这些底物在合成中是特别有吸引力的伙伴。氨基甲酸酯官能化/位点选择性交叉偶联过程的顺序使用突出了该方法的实用性。
We report the amination of aryl carbamates using nickel-catalysis. The methodology is broad in scope with respect to both coupling partners and delivers aminated products in synthetically useful yields. Computational studies provide the full catalytic cycle of this transformation, and suggest that reductive elimination is the rate-determining step. Given that carbamates are easy to prepare, robust, inert to Pdcatalysis, and useful for arene functionalization, these substrates are particularly attractive partners for use in synthesis. The sequential use of carbamate functionalization/site-selective cross-coupling processes highlights the utility of this methodology.