Haemostatic factors associated with ischaemic heart disease in men aged 45 to 64 years. The Speedwell study.
Haemostatic factors associated with ischaemic heart disease in men aged 45 to 64 years. The Speedwell study.
复制标题
与 45 至 64 岁男性缺血性心脏病相关的止血因素。
作者：
I. Baker;R. Eastham;P. Elwood;M. Etherington;J. O'Brien;P. Sweetnam
在 Speedwell 研究中，主要检查从 16 名全科医生的实践中随机抽取的 45 至 64 岁男性的血脂与缺血性心脏病的关系，测量了可能有助于血栓形成和动脉粥样硬化形成的各种止血因素。通过比浊法测量的纤维蛋白原和血浆粘度与缺血性心脏病的患病率呈正相关。抗凝血酶 III 与缺血性心脏病的患病率呈负相关。这些关联在 1% 的概率水平上具有统计显着性。通过凝血方法测量的纤维蛋白原和贫血小板血浆的肝素中和活性分别与缺血性心脏病呈负相关和正相关，但两种相关性均未达到统计学显着性。由于这些变量与年龄的相互关系，对纤维蛋白原的两种测量值分别进行了多重逻辑回归分析。 “可凝”纤维蛋白原的负相关以及血浆粘度与缺血性心脏病患病率的正相关已得到证实，并且两者在 5% 的概率水平上均具有统计学显着性。除年龄外，其他变量与缺血性心脏病的独立相关性并未达到统计学显着性。两种方法测量的纤维蛋白原与血清总胆固醇呈正相关且具有统计学显着性相关性，但与血清总甘油三酯、吸烟或饮酒没有相关性。与血清高密度脂蛋白胆固醇呈负相关且统计学上不显着。观察到的关联支持了一些止血因素参与缺血性心脏病病因学的概念，并且这些关联现在正在纵向研究中得到更严格的检验。
In the Speedwell study set up to examine primarily the relation of plasma lipids and ischaemic heart disease in men aged 45 to 64 years drawn randomly from the practices of 16 general practitioners, various haemostatic factors which may contribute both to thrombogenesis and atherogenesis were measured. Fibrinogen measured nephelometrically and plasma viscosity were positively associated with the prevalence of ischaemic heart disease. Antithrombin III was negatively associated with the prevalence of ischaemic heart disease. These associations were statistically significant at the 1% level of probability. Fibrinogen measured by a clotting method and the heparin neutralising activity of platelet poor plasma had negative and positive associations with ischaemic heart disease, respectively, but neither association achieved statistical significance. Because of the interrelation of these variables and also age, a multiple logistic regression analysis was undertaken separately for the two measures of fibrinogen. The negative association of "clottable' fibrinogen and the positive association of plasma viscosity with the prevalence of ischaemic heart disease were confirmed and both were statistically significant at the 5% level of probability. Apart from age the independent association of the other variables with ischaemic heart disease did not achieve statistical significance. Fibrinogen measured by both methods had positive and statistically significant associations with serum total cholesterol, but no associations with serum total triglycerides, smoking, or alcohol consumption. "Clottable' fibrinogen had an inverse and statistically insignificant association with serum high density lipoprotein cholesterol. The observed associations support the concept of the involvement of some haemostatic factors in the aetiology of ischaemic heart disease, and these associations are now being examined more critically in a longitudinal study.