Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
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DOI：
10.1038/nn.2377
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发表时间：
2009-09-01
影响因子：
25
通讯作者：
Fawcett, James W.
中科院分区：
文献类型：
--
作者：
Garcia-Alias, Guillermo;Barkhuysen, Stanley;Fawcett, James W.
软骨素酶ABC治疗促进脊髓可塑性。我们研究了软骨素酶诱导的可塑性与物理康复相结合是否能促进颈髓损伤大鼠手灵巧性的恢复。大鼠接受C4背索切割，然后使用软骨素酶ABC或青霉素酶作为对照。他们被分配到两个替代的康复程序，第一个加强熟练的达到和第二个加强一般运动。软骨素酶治疗增强了皮质脊髓轴突的发芽独立的康复制度。只有接受软骨素酶和特定康复组合的大鼠表现出改善的手灵巧性。接受一般运动康复治疗的大鼠在爬梯行走方面表现更好，但与未接受治疗的大鼠相比，熟练达到的能力更差。我们的研究结果表明，硫酸软骨素酶治疗打开了一个窗口，在此期间，康复可以促进恢复。然而，只有经过培训的技能得到提高，其他功能可能会受到负面影响。
Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penicillinase as a control. They were assigned to two alternative rehabilitation procedures, the first reinforcing skilled reaching and the second reinforcing general locomotion. Chondroitinase treatment enhanced sprouting of corticospinal axons independently of the rehabilitation regime. Only the rats receiving the combination of chondroitinase and specific rehabilitation showed improved manual dexterity. Rats that received general locomotor rehabilitation were better at ladder walking, but had worse skilled-reaching abilities than rats that received no treatment. Our results indicate that chondroitinase treatment opens a window during which rehabilitation can promote recovery. However, only the trained skills are improved and other functions may be negatively affected.