The psychophysiology of anxiety disorder: Fear memory imagery
The psychophysiology of anxiety disorder: Fear memory imagery
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DOI：
10.1111/1469-8986.00043
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发表时间：
2003-05-01
期刊：
影响因子：
3.7
通讯作者：
Bradley, MM
中科院分区：
文献类型：
--
作者：
Cuthbert, BN;Lang, PJ;Bradley, MM
在特定恐怖症、社交焦虑症、惊恐障碍伴广场恐怖症、创伤后应激障碍（PTSD）和健康对照组中评估了对恐惧记忆意象的心理生理反应。心率，皮肤电导，和皱眉肌被记录为参与者响应的音调提示信号先前记住的描述性句子。图像内容包括个人恐惧、社会恐惧、对身体危险的恐惧和中性（低唤醒）场景。在回忆图像和非信号期间评估对声学惊吓探针（眨眼）的反应。与中性线索相比，参与者对恐惧的反应（在生理学和情感报告方面）更显着。然而，恐慌和创伤后应激障碍患者的生理反应比特定恐惧症和社交焦虑症患者要少。惊恐和创伤后应激障碍患者也报告了最多的焦虑和情绪症状，最常见的是共病抑郁。总的来说，对句子记忆线索的生理反应在对特定物体或事件具有局部恐惧的患者中最大，并且在以广泛的、高负面影响为特征的患者中减少。
Psychophysiological response to fear memory imagery was assessed in specific phobia, social anxiety disorder, panic disorder with agoraphobia, post-traumatic stress disorder (PTSD), and healthy controls. Heart rate, skin conductance, and corrugator muscle were recorded as participants responded to tone cues signaling previously memorized descriptor sentences. Image contents included personal fears, social fears, fears of physical danger, and neutral (low arousal) scenes. Reactions to acoustic startle probes (eyeblink) were assessed during recall imagery and nonsignal periods. Participants were significantly more reactive (in physiology and report of affect) to fear than neutral cues. Panic and PTSD patients were, however, less physiologically responsive than specific phobics and the socially anxious. Panic and PTSD patients also reported the most anxiety and mood symptoms, and were most frequently comorbidly depressed. Overall, physiological reactivity to sentence memory cues was greatest in patients with focal fear of specific objects or events, and reduced in patients characterized by generalized, high negative affect.