Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation.
Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation.
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闭塞性细支气管炎组织性肺炎是同种异体骨髓移植的并发症。
DOI：
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发表时间：
1992
影响因子：
4.8
通讯作者：
Robert B. Geller
中科院分区：
文献类型：
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作者：
M. Thirman;Steven M. Devine;K. O’Toole;G. Cizek;Jose Jessurun;Marshall I. Hertz;Robert B. Geller
我们报告一位因慢性粒细胞白血病接受过两次异基因骨髓移植的病人，第一次是在1984年，在1990年复发后，他在每次移植后的相似间隔内出现了相同的肺综合征。患者出现无效咳嗽，双侧吸气嘎嘎声，胸部X光片显示多发斑片状浸润物。肺功能检查显示限制性异常，但无梗阻性缺陷。每次移植后出现这种肺部疾病与慢性移植物抗宿主病的发展是一致的。在这两种情况下，这种肺综合征通过皮质类固醇治疗完全逆转。患者的胸部CT扫描和肺活检标本与闭塞性细支气管炎合并机化性肺炎(BOOP)的诊断一致。虽然同种异体移植后有闭塞性细支气管炎的报道，但BOOP在此之前还没有报道过。
We report a patient who underwent two allogeneic bone marrow transplants for chronic myelogenous leukemia, initially in 1984 and again after relapse in 1990, who developed an identical pulmonary syndrome at a similar interval following each transplant. The patient presented with a non-productive cough, bilateral inspiratory crackles, and multiple patchy infiltrates on chest X-ray. Pulmonary function testing revealed a restrictive abnormality but no obstructive defects. The appearance of this pulmonary disorder after each transplant coincided with the development of chronic graft-versus-host disease. In both instances, this pulmonary syndrome completely reversed with corticosteroid therapy. The patient's chest computed tomographic scan and lung biopsy specimens were consistent with the diagnosis of bronchiolitis obliterans with organizing pneumonia (BOOP). While bronchiolitis obliterans has been reported following allogeneic transplant, BOOP has not previously been reported in this setting.