4-Nitroquinoline 1-oxide-induced pulmonary endocrine cell hyperplasia in Syrian golden hamster.
4-Nitroquinoline 1-oxide-induced pulmonary endocrine cell hyperplasia in Syrian golden hamster.
复制标题
4-硝基喹啉 1-氧化物诱导叙利亚金仓鼠肺内分泌细胞增生。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Kanisawa
中科院分区：
文献类型：
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作者：
T. Ito;H. Kitamura;Y. Inayama;M. Kanisawa
通过光学和电子显微镜检查了 4-硝基喹啉 1-氧化物 (4NQO) 对仓鼠肺的致瘤作用。仓鼠每周接受 3 次 4NQO 皮下注射，剂量为 20 mg/kg 体重，并在第一次注射后 20、25 和 30 周处死。通过对所有治疗动物的肺组织切片进行连续切片，从叶支气管到细支气管-肺泡交界区的气道中一致证实了增生性内分泌细胞病变。增生性病变含有嗜银细胞，并对神经元特异性烯醇化酶表现出弱阳性免疫反应性。从超微结构上看，一些细胞含有小核致密颗粒。
The tumorigenic effects of 4-nitroquinoline 1-oxide (4NQO) on the hamster lung were examined by light and electron microscopy. The hamsters received three subcutaneous injections of 4NQO at a dose of 20 mg/kg body weight at weekly intervals, and were sacrificed at 20, 25, and 30 weeks after the first injection. Hyperplastic endocrine cell lesions were consistently demonstrated in the airway from the lobar bronchi to the bronchiolo-alveolar junctional area by serial sectioning of lung tissue slices of all the treated animals. The hyperplastic lesions contained argyrophilic cells and showed weakly positive immunoreactivity to neuron-specific enolase. Ultrastructurally, some of the cells contained small cored dense granules.
仓鼠肺心下叶中的小颗粒（神经）内分泌细胞。
影响因子：
1.7
作者：
HoytJr,RF;Sorokin,SP;Feldman,H
通讯作者：
Feldman,H