Tumorigenicityof Dihydrodiolsand Diol-Epoxidesof Benz(c)acridinein NewbornMice
Tumorigenicityof Dihydrodiolsand Diol-Epoxidesof Benz(c)acridinein NewbornMice
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苯并吖啶二氢二醇和二醇环氧化物对新生小鼠的致瘤性
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
A. Conney
中科院分区：
文献类型：
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作者：
R. Chang;W. Levin;A. Wood;Subodh Kumar;H. Yagi;D. Jerina;R. Lehr;A. Conney
在新生小鼠中评价了苯并（c）吖啶（B（c）ACR）及其衍生物的致瘤性，所述衍生物包括五种代谢上可能的反式二氢二醇、非对映体的湾区二醇环氧化物、两种非湾区二醇环氧化物和K区5，6-氧化物。总剂量为0.50或1.05 /？对断奶前的小鼠腹膜内给予100 μ mol化合物，当小鼠为33 - 37周龄时测定致瘤活性。B（c）ACR是一种弱致癌物，在1.05~/？mol剂量。在B（c）ACR的五种可能的代谢的反式-二氢二醇中，仅反式-3，4-二羟基-3，4-二氢-B（c）ACR（B（c）ACR 3，4-二氢二醇）具有高致瘤活性。B（cJACR 3，4-dihydrodiol）诱导的肺和肝肿瘤分别是母体的2倍和10倍
The tumorigenicity of benz(c jacridine (B(c)ACR) and a number of its derivatives, including the five metabolically possible trans- dihydrodiols, the diastereomeric bay-region diol-epoxides, two non-bay-region diol-epoxides, and the K-region 5,6-oxide, were assessed in newborn mice. A total dose of 0.50 or 1.05 /Â?mol of compound was administered i.p. to preweanling mice, and tu- morigenic activity was determined when the mice were 33 to 37 weeks old. B(c)ACR was a weak carcinogen producing an average of 2.5 lung tumors/mouse and 0.15 liver tumor/male mouse at the 1.05~/Â?mol dose. Of the five metabolically possible frans-dihydrodiols of B(c)ACR, only frans-3,4-dihydroxy-3,4-di- hydro-B(c)ACR (B(c)ACR 3,4-dihydrodiol) had high tumorigenic activity. B(cJACR 3,4-dihydrodiol induced 2- and 10-fold more pulmonary and hepatic tumors, respectively, than did the parent
苯（a）吖啶和苯（c）吖啶的二醇环氧化物和四氢环氧化物在细菌和哺乳动物细胞中的致突变性。
影响因子：
11.2
作者：
Wood,AW;Chang,RL;Levin,W;Ryan,DE;Thomas,PE;Lehr,RE;Kumar,S;Schaefer-Ridder,M;Engelhardt,U;Yagi,H;Jerina,DM;Conney,AH
通讯作者：
Conney,AH
苯并[c]吖啶及其十二种衍生物对小鼠皮肤的肿瘤引发活性。
影响因子：
11.2
作者：
Levin,W;Wood,AW;Chang,RL;Kumar,S;Yagi,H;Jerina,DM;Lehr,RE;Conney,AH
通讯作者：
Conney,AH