Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges
Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges
复制标题
DOI：
10.1016/j.bcp.2012.12.014
复制
发表时间：
2013-04-15
影响因子：
5.8
通讯作者：
Schwarcz, Robert
中科院分区：
文献类型：
--
作者：
Albuquerque, Edson X.;Schwarcz, Robert
犬尿烯酸（KYNA）是一种主要的色氨酸代谢物，是谷氨酸受体拮抗剂，据报道也可抑制α 7烟碱乙酰胆碱受体（α 7 nAChR）。由于实验方法的变化，关于KYNA直接影响α 7nAChR功能的能力出现了争议。在这里，我们总结了目前的概念，KYNA神经生物学和审查有关的证据提出的作用KYNA作为一种内源性调制器的α 7nAChRs和突触传递。由于α 7 nAChR的功能障碍在中枢神经系统疾病的病理生理学中起主要作用，因此阐明KYNA对该受体亚型的作用具有显著的治疗意义。(C)2013年由Elsevier Inc.出版
Kynurenic acid (KYNA), a major tryptophan metabolite, is a glutamate receptor antagonist, which is also reported to inhibit alpha 7 nicotinic acetylcholine receptors (alpha 7nAChRs). Due to variations in experimental approaches, controversy has arisen regarding the ability of KYNA to directly influence alpha 7nAChR function. Here we summarize current concepts of KYNA neurobiology and review evidence pertaining to the proposed role of KYNA as an endogenous modulator of alpha 7nAChRs and synaptic transmission. As dysfunction of alpha 7nAChRs plays a major role in the pathophysiology of central nervous system disorders, elucidation of KYNA's action on this receptor subtype has significant therapeutic implications. (C) 2013 Published by Elsevier Inc.