Spatial and Temporal Brain Responses to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome
Spatial and Temporal Brain Responses to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome
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DOI：
10.1177/0022034516653580
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发表时间：
2016-09-01
影响因子：
7.6
通讯作者：
Taira, M.
中科院分区：
文献类型：
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作者：
Shinozaki, T.;Imamura, Y.;Taira, M.
灼口综合征（BMS）是一种特发性口面部疼痛。虽然BMS的病理生理学还不清楚，但认为涉及中枢和外周神经病理机制。作者比较了16名原发性BMS右利手女性和15名性别和年龄匹配的右利手健康女性对照组对有害热刺激的大脑反应。在一个循环中重复4次32 ° C至40 ° C至32 ° C至49 ° C的热刺激序列。将Peltier热电极放置在右手掌或右下唇上，每次32 s。功能磁共振成像数据通过记录回波平面图像与块设计。统计参数映射8软件用于分析数据。患者和对照组均报告在手掌刺激期间比在嘴唇刺激期间感觉更多的疼痛。在下唇上重复有害的热刺激，而不是在手掌上诱导扣带皮层的大脑活动习惯化，而不会减少疼痛感知。多元回归分析显示，感知疼痛强度和抑制大脑活动的前扣带皮层时，重复的热序列施加在下唇之间的相关性。此外，当在手掌处施加相同的重复热序列时，BMS患者和对照组的海马旁区的反应不同。作者的研究结果表明，BMS患者由于中枢和外周神经系统功能受损而表现出特定的脑反应（临床试验注册号：UMIN000015002）。
Burning mouth syndrome (BMS) is an idiopathic orofacial pain condition. Although the pathophysiology of BMS is not clearly understood, central and peripheral neuropathic mechanisms are thought to be involved. The authors compared brain response to noxious heat stimuli in 16 right-handed women with primary BMS and 15 sex-and age-matched right-handed healthy female controls. A thermal stimulus sequence of 32 degrees C to 40 degrees C to 32 degrees C to 49 degrees C was repeated 4 times in a cycle. Warm and noxious heat stimuli were delivered with a Peltier thermode placed on the right palm or right lower lip for 32 s each in a session. Functional magnetic resonance imaging data were obtained by recording echoplanar images with a block design. Statistical Parametric Mapping 8 software was used to analyze the data. Patients and controls both reported feeling more pain during palm stimulation than during lip stimulation. Repetition of noxious heat stimulus on the lower lip but not on the palm induced habituation in brain activity in the cingulate cortex without reduction in pain perception. Multiple regression analysis revealed a correlation between perceived pain intensity and suppression of brain activity in the anterior cingulate cortex when the repeated thermal sequence was applied at the lower lip. Furthermore, the response of the parahippocampal area differed in BMS patients and controls when the same repeated thermal sequence was applied at the palm. The authors' findings indicate that BMS patients show specific brain responses due to impaired function of the central and peripheral nervous systems (clinical trial registration: UMIN000015002).