Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1
Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1
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DOI：
10.1016/j.neulet.2004.01.026
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发表时间：
2004-04-01
影响因子：
2.5
通讯作者：
Okano, H
中科院分区：
文献类型：
--
作者：
Ohba, H;Chiyoda, T;Okano, H
Sox21是一种高迁移率的群盒转录因子，在胚胎鼠脑的未成熟神经干/祖细胞群中均有表达，而在皮层板中无表达，在成年鼠脑中仅表达于脑室下区。在未分化的pc12细胞中，检测到内源性Sox21的表达，但其表达在神经生长因子（NGF）诱导的神经元分化过程中停止。在PC12细胞中，Sox21的过表达导致ngf诱导的神经突生长的实质性抑制。此外，我们通过生化方法鉴定了一种Sox21相关蛋白，即Y-box结合蛋白I，它不仅能与Sox21结合，还能部分恢复被Sox21抑制的ngf诱导的PC12细胞的神经突生长。这些结果表明Sox21是发育中的神经系统中神经元分化的抑制因子。2004爱思唯尔爱尔兰有限公司版权所有。
Sox21, a high-mobility group box transcription factor, is expressed throughout the immature neural stem/progenitor population in ventricular zone but not in the cortical plate in embryonic mouse brain and its expression is restricted to the subventricular zone in the adult brain. In undifferentiated PC 12 cells, endogenous Sox21 expression is detected but its expression ceases during the nerve growth factor (NGF)-induced neuronal differentiation. Overexpression of Sox21 results in a substantial repression of NGF-induced neurite outgrowth in PC12 cells. Further, we biochemically identified a Sox21-associating protein, Y-box binding protein I which not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21. These results suggest that Sox21 is a repressor of neuronal differentiation in the developing nervous system. (C) 2004 Elsevier Ireland Ltd. All rights reserved.