MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: status report
MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: status report
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DOI：
10.1016/s0720-048x(00)00195-9
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发表时间：
2000-06-01
影响因子：
3.3
通讯作者：
Turetschek, K
中科院分区：
文献类型：
--
作者：
Brasch, R;Turetschek, K
大分子造影剂增强的磁共振成像（MRI）已成功应用于检测肿瘤微血管特征。这些MRI检测的特征与组织学微血管密度密切相关，微血管密度是肿瘤血管生成的既定替代物，并且与病理肿瘤分级密切相关。MMCM增强MRI用于特纳表征的实用性已经在一系列癌症类型（包括乳腺癌、卵巢癌、前列腺纤维肉瘤）中通过实验建立。MMCM增强MRI技术也可用于监测血管生成抑制剂（血管内皮生长因子（VEGF）抗体）给药引起的肿瘤血管变化。抑制微血管通透性（高达98%）诱导的这种抑制剂的血管生成的检测和定量治疗开始后24小时。因此，肿瘤微血管特征，特别是大分子渗透性的MRI测定，提供了一种非侵入性表征肿瘤的方法，用于治疗的个性化和优化，以及用于监测治疗反应。在药物试验成功完成之前，现在正在进行中，MMCM的可用性应该允许这些强大的技术在临床实践中的立即应用。(C)2000爱思唯尔科学爱尔兰有限公司版权所有。
Magnetic resonance imaging (MRI) enhanced with a macromolecular contrast medium (MMCM) has been applied successfully to assay tumor microvascular characteristics. These MRI-assayed characteristics correlate closely with histologic microvascular density, an established surrogate of tumor angiogenesis, and with pathologic tumor grade. The utility of MMCM-enhanced MRI for turner characterizations has been established experimentally in a range of cancer types including breast, ovary, fibrosarcoma prostate. The MMCM-enhanced MRI technique can also be applied to monitor changes in tumor vessels that result from administration of an angiogenesis inhibitor, antibody against vascular endothelial growth factor (VEGF). Suppression of microvascular permeability (up to 98%) induced by this inhibitor of angiogenesis was detected and quantified as soon as 24 h after initiation of therapy. Thus, MRI assays of tumor microvascular characteristics, particularly macromolecular permeability, provide a means to non-invasively characterize tumors for prognostication, for individualization and optimization of treatment, and for monitoring therapeutic response. Pending successful completion of drug trials, now in progress, the availability of MMCM should permit the immediate application of these powerful techniques in clinical practice. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.