Increased rat testicular heme oxygenase activity associated with depressed microsomal heme and cytochrome P-450 levels after repeated administration of human chorionic gonadotropin.
Increased rat testicular heme oxygenase activity associated with depressed microsomal heme and cytochrome P-450 levels after repeated administration of human chorionic gonadotropin.
复制标题
重复施用人绒毛膜促性腺激素后，大鼠睾丸血红素加氧酶活性增加，与微粒体血红素和细胞色素 P-450 水平降低相关。
DOI：
10.1016/0003-9861(86)90014-7
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发表时间：
1986
影响因子：
3.9
通讯作者：
W. Piper
中科院分区：
文献类型：
--
作者：
E. Sadler;V. Reddy;W. Piper
Repeated administration of human chorionic gonadotropin to rats results in a maximal depression of testicular microsomal heme and cytochromeP-450 levels at 24 h, followed by increases that plateau at pretreatment levels by day six. Associated with the depressed levels of microsomal heme and cytochromeP-450 is an increase of testicular microsomal heme oxygenase activity at 12–24 h. Testicular mitochondrial δ-aminolevulinic acid synthase activity was increased at 24 h, and remained elevated throughout the 9-day treatment period. Pretreatment with 1,4,6-androstatrien-3,17-dione, an aromatase inhibitor, failed to prevent the depression of testicular microsomal heme or cytochromeP-450 or increased heme oxygenase activity caused by repeated administration of human chorionic gonadotropin, and administration of estradiol benzoate failed to alter testicular microsomal heme oxygenase activity suggesting that these parameters were not related to altered testicular estrogen content caused by increased aromatase activity. These results suggest that increased testicular heme oxygenase activity is associated with decreased microsomal heme and cytochromeP-450 content during human chorionic gonadotropin-induced desensitization.
苯甲酸雌二醇抑制大鼠睾丸血红素合成并抑制微粒体细胞色素 P-450。
影响因子：
5.8
作者：
Tofilon,PJ;Piper,WN
通讯作者：
Piper,WN
1,2-二溴-3-氯丙烷抑制大鼠睾丸血红素的生物合成。
影响因子：
5.8
作者：
Tofilon,PJ;Clement,RP;Piper,WN
通讯作者：
Piper,WN