Gastric emptying and small intestinal propulsion in fed and fasted rats.
Gastric emptying and small intestinal propulsion in fed and fasted rats.
复制标题
进食和禁食大鼠的胃排空和小肠推进。
DOI：
10.1016/s0016-5085(73)80008-3
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发表时间：
1973
期刊：
影响因子：
29.4
通讯作者：
T. H. Kent
中科院分区：
文献类型：
--
作者：
L. Poulakos;T. H. Kent
开发了一种同时和独立测量大鼠胃排空和小肠推进的技术，并用于描述24小时禁食和进食大鼠的这些参数。放射性同位素51 Cr和125 I的不同发射能量允许分别测定Na 251 CrO 4和125 I-聚乙烯吡咯烷酮在胃内和/或十二指肠内同时给予这些不可吸收标记物后不同时间的分布。两组大鼠的同位素胃排空均呈指数变化，但禁食组的排空速度比进食组快得多。标记物胃内给药后，禁食和进食大鼠之间小肠中的分布也存在显著差异，禁食动物中大部分标记物移动更快。十二指肠内给予标记物后，禁食和进食大鼠在小肠中的分布非常相似。与放射性同位素的分布相反，小肠活动前沿的运动速率受胃排空的影响不大。
A technique for simultaneous and independent measurement of gastric emptying and small intestinal propulsion in rats was developed and utilized to describe these parameters in 24-hr fasted and fed rats. The differing emission energies of the radioisotopes51Cr and125I allowed separate determination of the distribution of Na251CrO4and125I-polyvinylpyrrolidone at various times after simultaneous intragastric and/or intraduodenal administration of these nonabsorbable markers. Gastric emptying of isotopes was exponential in both groups but much more rapid in fasted than fed rats. There was also a considerable difference in distribution in the small intestine between fasted and fed rats after intragastric administration of the markers with the bulk of the marker moving faster in fasted animals. After intraduodenal administration of the markers, the distribution in the small intestine was quite similar for fasted and fed rats. In contrast to the distribution of radioisotope, the rate of movement of the leading edge of activity in the small intestine was not greatly influenced by gastric emptying.