Sex‐specific mediation effect of the right fusiform face area volume on the association between variants in repeat length of AVPR1A RS3 and altruistic behavior in healthy adults
Sex‐specific mediation effect of the right fusiform face area volume on the association between variants in repeat length of AVPR1A RS3 and altruistic behavior in healthy adults
复制标题
DOI：
10.1002/hbm.23203
复制
发表时间：
2016-07
影响因子：
4.8
通讯作者：
Junping Wang;W. Qin;Feng Liu;Bing Liu;Yuan Zhou;T. Jiang;Chunshui Yu
中科院分区：
文献类型：
--
作者：
Junping Wang;W. Qin;Feng Liu;Bing Liu;Yuan Zhou;T. Jiang;Chunshui Yu
精氨酸加压素受体1A基因（AVPR 1A）RS3中的微卫星变异与正常社会行为变异和自闭症谱系障碍（ASD）以性别特异性方式相关。然而，这些关联背后的神经机制在很大程度上仍然未知。我们假设AVPR 1A RS3变体通过以性别特异性方式调节特定脑区的灰质体积（GMV）来影响利他行为。我们调查了278名年轻健康的成年人使用独裁者游戏来评估利他行为。对所有受试者进行基因分型，并以体素方式评估AVPR 1A RS3重复多态性的主要影响和基因型与性别对GMV的相互作用。我们观察到，男性受试者与相对较短的重复分配较少的钱给别人，并表现出显着较小的GMV在右侧梭状面区（FFA）相比，男性长纯合子。在男性受试者中，右侧FFA的GMV与利他行为呈显著正相关。混合中介和调节分析进一步揭示了右FFA的GMV对AVPR 1A RS3重复多态性和分配总和之间的关联具有显著的中介作用，性别（仅在男性中）对中介作用具有显著的调节作用。事后分析显示，携带等位基因426的男性受试者的右侧FFA的GMV显著小于非426携带者。这些结果表明，右FFA的GMV可能是AVPR 1A RS3中的遗传变异影响健康男性受试者利他行为的潜在介质。《脑地图》37：2700-2709，2016年。© 2016 Wiley Periodicals，Inc.
Microsatellite variants in the arginine vasopressin receptor 1A gene (AVPR1A) RS3 have been associated with normal social behaviors variation and autism spectrum disorders (ASDs) in a sex‐specific manner. However, neural mechanisms underlying these associations remain largely unknown. We hypothesized that AVPR1A RS3 variants affect altruistic behavior by modulating the gray matter volume (GMV) of specific brain regions in a sex‐specific manner. We investigated 278 young healthy adults using the Dictator Game to assess altruistic behavior. All subjects were genotyped and main effect of AVPR1A RS3 repeat polymorphisms and interaction of genotype‐by‐sex on the GMV were assessed in a voxel‐wise manner. We observed that male subjects with relatively short repeats allocated less money to others and exhibited a significantly smaller GMV in the right fusiform face area (FFA) compared with male long homozygotes. In male subjects, the GMV of the right FFA exhibited a significant positive correlation with altruistic behavior. A mixed mediation and moderation analysis further revealed both a significant mediation effect of the GMV of the right FFA on the association between AVPR1A RS3 repeat polymorphisms and allocation sums and a significant moderation effect of sex (only in males) on the mediation effect. Post hoc analysis showed that the GMV of the right FFA was significantly smaller in male subjects carrying allele 426 than in non‐426 carriers. These results suggest that the GMV of the right FFA may be a potential mediator whereby the genetic variants in AVPR1A RS3 affect altruistic behavior in healthy male subjects. Hum Brain Mapp 37:2700–2709, 2016. © 2016 Wiley Periodicals, Inc.