Age differences in behavior and PET activation reveal differences in interference resolution in verbal working memory
Age differences in behavior and PET activation reveal differences in interference resolution in verbal working memory
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DOI：
10.1162/089892900561823
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发表时间：
2000-01-01
影响因子：
3.2
通讯作者：
Hartley, A
中科院分区：
文献类型：
--
作者：
Jonides, J;Marshuetz, C;Hartley, A
老年人在使用物品识别范式的口头工作记忆任务中进行了测试。在这个任务的一些试验中，通过呈现熟悉的测试项目，但不是存储在内存中的当前项目集的成员，产生了反应冲突。这些问题需要消极的回答，但对它们的熟悉程度使被试倾向于积极的回答。年轻的受试者在这样的实验中表现出干扰效应，这种干扰伴随着左侧前额皮质区域的激活。然而，没有证据表明该区域的激活与受试者表现出的干扰有因果关系。在目前的研究中，我们证明了老年人在这项任务中比年轻人表现出更多的行为干扰，并且他们在相同的外侧前额叶部位也没有表现出可靠的激活。由此得出结论，这一前额叶部位在功能上参与调解工作记忆中冲突反应或冲突表征之间的解决。
Older adults were tested on a verbal working memory task that used the item-recognition paradigm. On some trials of this task, response-conflict was created by presenting test-items that were familiar but were not members of a current set of items stored in memory. These items required a negative response, but their familiarity biased subjects toward a positive response. Younger subjects show an interference effect on such trials, and this interference is accompanied by activation of a region on left lateral prefrontal cortex. However, there has been no evidence that the activation in this region is causally related to the interference that the subjects exhibit. In the present study, we demonstrate that older adults show more behavioral interference than younger subjects on this task, and they also show no reliable activation at the same lateral prefrontal site. This leads to the conclusion that this prefrontal site is functionally involved in mediating resolution among conflicting responses or among conflicting representations in working memory.