The Los Alamos hepatitis C sequence database
The Los Alamos hepatitis C sequence database
复制标题
DOI：
10.1093/bioinformatics/bth485
复制
发表时间：
2005-02-01
期刊：
影响因子：
5.8
通讯作者：
Richardson, R
中科院分区：
文献类型：
--
作者：
Kuiken, C;Yusim, K;Richardson, R
动机：丙型肝炎病毒（HCV）是全球公共卫生的重大威胁。这种病毒变异性很大，进化迅速，使其成为免疫系统以及疫苗和药物设计的一个难以捉摸的目标。目前，已发表约30000个HCV序列。一个中央网站，提供注释的序列和分析工具将有助于HCV科学家worldwide.Results：HCV序列数据库收集和注释序列数据，并通过一个网站，包含一个用户友好的搜索界面和大量的序列分析工具，提供给公众，高度重视的洛斯阿拉莫斯HIV数据库的模型的基础上。HCV序列数据库于2003年9月正式启动。从那时起，它的使用量稳步增长，现在平均每天从不同的IP地址访问280次。
Motivation: The hepatitis C virus (HCV) is a significant threat to public health worldwide. The virus is highly variable and evolves rapidly, making it an elusive target for the immune system and for vaccine and drug design. At present, some 30 000 HCV sequences have been published. A central website that provides annotated sequences and analysis tools will be helpful to HCV scientists worldwide.Results: The HCV sequence database collects and annotates sequence data and provides them to the public via a website that contains a user-friendly search interface and a large number of sequence analysis tools, based on the model of the highly regarded Los Alamos HIV database. The HCV sequence database was officially launched in September 2003. Since then, its usage has steadily increased and is now at an average of similar to280 visits per day from distinct IP addresses.