Abnormal Secretion of Glycoprotein α-Subunit and Follicle-Stimulating Hormone (FSH) β-Subunit in Men with Pituitary Adenomas and FSH Hypersecretion
Abnormal Secretion of Glycoprotein α-Subunit and Follicle-Stimulating Hormone (FSH) β-Subunit in Men with Pituitary Adenomas and FSH Hypersecretion
复制标题
男性垂体腺瘤和 FSH 分泌过多的糖蛋白 α 亚基和卵泡刺激素 (FSH) β 亚基分泌异常
DOI：
10.1210/jcem-51-3-579
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
R. Muzyka
中科院分区：
文献类型：
--
作者：
P. Snyder;Ja Johnson;R. Muzyka
对12例伴有选择性FSH分泌过多的垂体腺瘤患者血清糖蛋白α亚基和FSH β亚基浓度进行了基础和促性腺激素释放激素（GnRH）反应性测定。在原发性性腺功能减退和血清FSH浓度升高到与垂体腺瘤患者相似程度的男性中，以及分别与垂体腺瘤患者和原发性性腺功能减退患者年龄匹配的两组正常男性中，也进行了相同的测定。由于完整FSH在α-亚基和FSH β-亚基试验中发生交叉反应，完整LH在α-亚基试验中发生交叉反应，因此根据完整激素的贡献校正了两种亚基的血清浓度值。用凝胶过滤层析法从FSH中分离FSH β-亚基，并测定其含量。垂体腺瘤患者血清α-亚单位对GnRH的反应低于垂体腺瘤患者。
The serum concentrations of the glycoprotein α-subunit and the FSH β-subunit were determined basally and in response to gonadotropin-releasing hormone (GnRH) in 12 men who had pituitary adenomas associated with selective hypersecretion of FSH. The same determinations were also made in men who had primary hypogonadism and serum FSH concentrations elevated to a degree similar to that of the men who had pituitary adenomas, as well as in two groups of normal men matched in age to the men with pituitary adenomas and the men with primary hypogonadism, respectively. Because intact FSH cross-reacted in the α-subunit and FSH β-subunit assays and intact LH cross-reacted in the α-subunit assay, the values for serum concentrations of both subunits were corrected for the contributions of the intact hormones. The FSH β-subunit was also determined in post-GnRH sera after separating it from intact FSH by gel filtration chromatography. The serum α-subunit response to GnRH was less in the men who had pituitary adenomas tha...