Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy
Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy
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DOI：
10.1016/j.biopha.2012.10.006
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发表时间：
2013-02-01
影响因子：
7.5
通讯作者：
Oishi, Ryozo
中科院分区：
文献类型：
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作者：
Tatsushima, Yoko;Egashira, Nobuaki;Oishi, Ryozo
以奥沙利铂为基础的化疗已广泛用于结直肠癌。然而，它会引起严重的急性和慢性周围神经病变。最近，我们报道了钙通道阻滞剂对奥沙利铂诱导的大鼠冷痛敏的预防作用。本研究的目的是确定在奥沙利铂治疗期间使用钙通道阻滞剂治疗是否可以预防周围神经病变。对2008年1月至2010年12月接受改良FOLFOX 6方案治疗的患者的电子病历进行评价。在接受改良FOLFOX 6治疗的200例患者中，84例患者因排除标准而被排除。69名男性患者中有26人服用了钙通道阻滞剂，而47名女性患者中只有3人服用了钙通道阻滞剂。因此，在本分析中，比较了使用和不使用钙通道阻滞剂组（分别为n = 26和43）的雄性数据。急性神经病变的累积发生率曲线在钙通道阻滞剂组中显著较低（P = 0.0438，对数秩检验），而慢性神经病变的累积发生率曲线在这些组之间没有差异（P = 0.4919，对数秩检验）。本研究表明，钙通道阻滞剂可抑制接受改良FOLFOX 6治疗的患者发生急性周围神经病变。(C)2012年Elsevier Masson SAS。All rights reserved.
Oxaliplatin-based chemotherapy has been widely used for colorectal cancer. However, it causes severe acute and chronic peripheral neuropathies. Recently, we reported that calcium channel blockers prevent the oxaliplatin-induced cold hyperalgesia in rats. The purpose of this study was to determine whether the treatment with calcium channel blockers prevents the peripheral neuropathy during oxaliplatin therapy. The electronic medical charts for patients who received modified FOLFOX6 regimen from January 2008 to December 2010 were evaluated. Of the 200 patients who received modified FOLFOX6 therapy, 84 patients were excluded due to the exclusion criteria. Calcium channel blockers had been taken by 26 of 69 male patients, but only three of 47 female patients. Therefore, in the present analysis, the male data of the groups with and without calcium channel blockers (n = 26 and 43, respectively) were compared. The cumulative incidence curve of acute neuropathy was significantly lower in the group with calcium channel blockers (P = 0.0438, log-rank test), whereas there was no difference between these groups in the cumulative incidence curve of chronic neuropathy (P = 0.4919, log-rank test). The present study indicated that calcium channel blockers inhibit the development of acute peripheral neuropathy in patients receiving modified FOLFOX6 therapy. (C) 2012 Elsevier Masson SAS. All rights reserved.