Recent advances in the molecular pathophysiology of atrial fibrillation
Recent advances in the molecular pathophysiology of atrial fibrillation
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DOI：
10.1172/jci46315
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发表时间：
2011-08-01
影响因子：
15.9
通讯作者：
Nattell, Stanley
中科院分区：
文献类型：
--
作者：
Wakili, Reza;Voigt, Niels;Nattell, Stanley
心房颤动（AF）是一种非常常见的心律失常，导致大量发病率和死亡率。房颤的机制是复杂的，既包括心房细胞自发异位放电的增加，也包括通过心房组织的脉冲再入。在过去的十年里，在理解潜在的分子病理生物学方面取得了巨大的进展。本文综述了心房颤动的基本机制和分子过程，讨论了心脏疾病状态、心外因素和异常遗传控制导致心律失常的途径。最后，我们讨论了潜在的治疗意义，这可能源于对机制的进一步了解。
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.