Polyurethane central venous catheters, hydrochloric acid and 70% ethanol: A safety evaluation
Polyurethane central venous catheters, hydrochloric acid and 70% ethanol: A safety evaluation
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DOI：
10.1177/0310057x9702500404
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发表时间：
1997-08-01
影响因子：
1.5
通讯作者：
Havill, JH
中科院分区：
文献类型：
--
作者：
McHugh, GJ;Wild, DJC;Havill, JH
将3组中心静脉导管（CVC）分别注入0.1%的盐酸、70%的乙醇和生理盐水（对照组），观察CVC的显微结构完整性，每天从远端切下1cm的一段。在扫描电子显微镜下检查所有切片，寻找管腔表面损伤或管壁变薄的证据。研究后期出现零星的细小表面凹陷，无任何明确的时间或给药相关模式。平均CVC壁厚度在研究期间没有显著变化（P = 0.15）。观察到乙醇处理导管的定性软化，这一发现限制了乙醇上升的RITE建议。0.1N HCl不会影响导管的结构安全性，当聚氨酯CVC堵塞时应考虑使用。
Three groups of polyurethane central venous catheters (CVC) were infused daily for twenty days with 0.1 normal hydrochloric acid, 70% ethanol and normal saline (control) respectively to look for any changes in microscopic structural integrity.A 1 cm segment was cut from the distal end of each CVC daily. All sections were examined in a scanning electron microscope, looking for evidence either of damage to the lumen surface or of wall thinning.No significant damage to the lumen surfaces was observed with either treatment. Sporadic fine surface-pitting appeared late in the study without any clear temporal or treatment-related pattern. The mean CVC wall thickness did not change significantly over the study period (P = 0.15). Qualitative softening of ethanol treated catheters was observed, and this finding limits rite recommendations for the rise of ethanol.0.1N HCl does nor compromise the structural safety of the catheters, and its use should be considered when polyurethane CVC become occluded.