Growth factors in preimplantation development: role of insulin and insulin-like growth factors.
Growth factors in preimplantation development: role of insulin and insulin-like growth factors.
复制标题
DOI：
--
复制
发表时间：
1997-09
期刊：
影响因子：
--
通讯作者：
S. Heyner
中科院分区：
文献类型：
--
作者：
S. Heyner
对许多哺乳动物着床前胚胎的体外研究表明，输卵管和子宫中含有刺激着床前胚胎细胞增殖和分化的生长因子。哺乳动物着床前胚胎最初被视为一个独立的实体，因为小鼠胚胎可以很容易地从双细胞阶段培养到囊胚。在对其他物种（尤其是家畜）进行研究后，这种观点发生了变化。研究发现，当胚胎在体外培养时，存在发育“障碍”。另一个证明母体环境对最佳发育至关重要的证据是，体外培养的胚胎发育滞后于体内的胚胎。当在培养基中加入生殖道清洗液或特定生长因子时，这种发育迟缓可以得到改善。在哺乳动物发育过程中，生长因子及其受体基因的表达受到组织特异性以及时间和空间的调控。本文就胰岛素家族多肽生长因子在哺乳动物着床前发育过程中的表达及作用进行综述。
In vitro studies of preimplantation embryos from a number of mammalian species have shown that the oviduct and uterus contain growth factors that stimulate cellular proliferation and differentiation of preimplantation embryos. The mammalian preimplantation embryo was first viewed as an autonomous entity, due to the ease with which mouse embryos could be cultured from the two-cell stage on to the blastocyst. This view changed following studies in other species, notably domestic animals, which revealed the presence of 'blocks' to development, when embryos were cultured in vitro. Another line of evidence leading to the view that the maternal environment is crucial for optimal development, was the finding that embryos cultured in vitro lag developmentally behind their in vivo counterparts. This developmental retardation could be ameliorated when washings from the reproductive tract or specific growth factors were added to the media. The expression of genes for growth factors and their receptors is regulated in a tissue-specific manner as well as temporally and spatially during mammalian development. In this review, information regarding the expression and role of polypeptide growth factors of the insulin family during preimplantation mammalian development is summarized.