COUPLING OF VENTILATION AND CO2 PRODUCTION DURING EXERCISE IN CHILDREN
COUPLING OF VENTILATION AND CO2 PRODUCTION DURING EXERCISE IN CHILDREN
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DOI：
10.1203/00006450-198706000-00012
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发表时间：
1987-06-01
影响因子：
3.6
通讯作者：
WASSERMAN, K
中科院分区：
文献类型：
--
作者：
COOPER, DM;KAPLAN, MR;WASSERMAN, K
本研究的目的是确定如何通气.ovrhdot.VE和CO2生产. ovrhdot. VCO 2在响应运动的变化在儿童和青少年的生长过程中。在两种类型的研究中测量动态气体交换反应：1）128名年龄在6至18岁范围内的健康儿童进行渐进运动试验（“斜坡”型方案），以测量VE和VCO 2之间关系的斜率。德尔塔... ovrhdot.E/. Δ.. ovrhdot.VCO2;（2）对11名青少年和11名年龄较小的儿童在休息和运动之间的转换过程中的VE和VCO 2的反应特征进行了测量。通过呼吸测量气体交换。我们发现Δ有一个小但显著的下降。ovrhdot.VE/.DELTA.. VCO 2随体重（r =-0.46，p < 0.05）、身高或年龄（最年轻受试者的平均斜率为27，最年长受试者的平均斜率为21）的增加而增加。VE和VCO 2的响应特征（以最佳拟合指数响应的时间常数测量）在年幼儿童和青少年中均长于VO 2;但VE和VCO 2的时间常数在年幼儿童中均比青少年快约30%。此外，年轻受试者（平均值为39.6 mmHg）运动期间潮气末PCO 2显著低于青少年（平均值为43.5 mmHg）。结果表明，运动中的呼吸控制过程在儿童时期成熟到一个小的程度，因为在年幼的儿童中，PCO 2可能被调节在较低的水平，并且可能存在与生长相关的差异，可以储存在组织中的CO2的相对量。
The purpose of this study was to determine how ventilation .ovrhdot.VE and CO2 production .ovrhdot.VCO2 in response to exercise change during the growth process in children and teenagers. Dynamic gas exchange responses were measured in two types of studies: 1) 128 healthy children ranging in age from 6 to 18 yr performed progressive exercise tests ("ramp" type protocol) for measurement of the slope of the relationship between .ovrhdot.VE and .ovrhdot.VCO2.sbd..DELTA..ovrhdot.E/.DELTA..ovrhdot.VCO2; and 2) the response characeristics of .ovrhdot.VE and .ovrhdot.VCO2 in the transition between rest and exercise were measured in 11 teenagers and 11 younger children. Gas exchange was measured breath by breath. We found a small but significant decrease in .DELTA..ovrhdot.VE/.DELTA..ovrhdot.VCO2 with increasing body weight (r = -0.46, p < 0.05), height, or age (mean slope of 27 in the youngest in 21 in the oldest subjects). The response characteristics of .ovrhdot.VE and .ovrhdot.VCO2 (measured as the time constant of the best-fit exponential response) were longer than for .ovrhdot.VO2 in both younger children and teenagers; but the time constants for .ovrhdot.VE and .ovrhdot.VCO2 were each approximately 30% faster in younger children compared to teenagers. In addition, end-tidal PCO2 during exercise was significantly lower in the younger subjects (mean value of 39.6 torr) compared to the teenagers (mean value of 43.5 torr). The results suggest that the process of respiratory control in exercise matures to a small degree during childhood in that PCO2 may be regulated at lower levels in younger children and there may be growth-related differences in the relative amounts of CO2 that can be stored in tissues.