TOTAL CORTISOL, FREE CORTISOL, AND GROWTH-HORMONE ASSOCIATED WITH BRIEF SOCIAL SEPARATION EXPERIENCES IN YOUNG MACAQUES
TOTAL CORTISOL, FREE CORTISOL, AND GROWTH-HORMONE ASSOCIATED WITH BRIEF SOCIAL SEPARATION EXPERIENCES IN YOUNG MACAQUES
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DOI：
10.1002/dev.420280402
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发表时间：
1995-05-01
影响因子：
2.2
通讯作者：
REITE, ML
中科院分区：
文献类型：
--
作者：
LAUDENSLAGER, ML;BOCCIA, ML;REITE, ML
许多行为，免疫和生理上的后果短暂分离的帽猴（Macaca辐射）和辫子猴（Macaca nemistrina）已被记录。然而，社会分离对这些特定物种血浆皮质醇和生长激素的影响尚不清楚。在本研究中，对社会饲养的帽猴和小辫猴婴儿分离2周后的行为和内分泌影响进行了跟踪研究。在研究期间，在7对（分离组和配对对照组）帽组和6对辫子组婴儿中，每周两次在基线、分离和团聚条件下获得血浆。在大约10分钟内从这对夫妇的两个婴儿身上采集了血液样本。在这些样本中测量血浆总皮质醇、游离皮质醇和生长激素。在整个研究期间，每天两次对所有受试者进行焦点动物行为观察。在这两个物种中，总皮质醇和游离皮质醇在母亲分离后与匹配的未分离对照组相比立即上升，并在与母亲团聚后恢复到基础水平（例如匹配的未分离对照组）。相比之下，血浆生长激素仅在辫状婴儿中上升，并在团聚前后达到峰值。多元回归技术表明，在分离的第一周，在分离而不是控制的受试者中，血浆游离皮质醇和总皮质醇与这一周观察到的痛苦行为（发声和姿势懒散）呈正相关，与同一时期观察到的社会行为（玩耍和接近他人）负相关。相比之下，血浆生长激素与受试者的物种和性别有关，但与行为变量无关。(C) 1995年，John Wiley & Sons, Inc。
Many behavioral, immunological, and physiological consequences of brief maternal separation in bonnet (Macaca radiata) and pigtail monkeys (Macaca nemistrina) have been documented. However, the impact of social separation on plasma cortisol and growth hormone is unknown for these particular species. In the present study, the behavioral and endocrinological consequences of a 2-week maternal separation in socially housed infant bonnet and pigtail monkeys were followed. In seven pairs (separated and matched control) of bonnet and six pairs of pigtail infants, plasma was obtained under baseline, separated, and reunion conditions twice weekly for the duration of the study. Blood samples were obtained from both infants of the pair in approximately 10 min. Plasma total cortisol, free cortisol, and growth hormone were measured in these samples. Focal animal behavioral observations were made on all subjects twice daily throughout the study period. In both species, total cortisol and free cortisol rose immediately following maternal separation in comparison to the matched nonseparated controls and returned to basal levels (e.g., that of matched nonseparated controls) following reunion with the mother. In contrast, plasma growth hormone rose only in the pigtail infants over a time course that peaked around the time of reunion. Multiple regression techniques indicated for the first week of separation, in the separated but not control subjects, that mean plasma free and total cortisol was positively related to distress behaviors (vocalization and postural slouch) observed during this week and negatively related to social behaviors (play and proximity to others) noted during the same period. In contrast, plasma growth hormone was related to both species and sex of the subjects but unrelated to behavioral variables. (C) 1995 by John Wiley & Sons, Inc.