Effects of intracoronary infusion of an inotropic agent, E-1020 (loprinone hydrochloride), on cardiac function: evaluation of left ventricular contractile performance using the end-systolic pressure-volume relationship.
Effects of intracoronary infusion of an inotropic agent, E-1020 (loprinone hydrochloride), on cardiac function: evaluation of left ventricular contractile performance using the end-systolic pressure-volume relationship.
复制标题
冠状动脉内输注正性肌力药物 E-1020（盐酸洛匹农）对心脏功能的影响：利用收缩末期压力-容积关系评估左心室收缩性能。
DOI：
10.1016/0167-5273(95)02397-f
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发表时间：
1995
影响因子：
3.5
通讯作者：
S. Morioka
中科院分区：
文献类型：
--
作者：
R. Murakami;K. Sano;Y. Murakami;T. Shimada;S. Morioka
The phosphodiesterase (PDE) III inhibitor, E-1020 (loprinone hydrochloride), has positive inotropic and vasodilating effects. This study evaluated the positive inotropic effect of intracoronary E-1020 in eight patients with coronary artery disease and hypertensive heart disease. A direct intracoronary infusion of the PDE III inhibitor minimizes its vasodilating effect. After baseline hemodynamic measurements and coronary arteriography, a micromanometer-tipped 8F conductance catheter was introduced into the left ventricle to determine the hemodynamic effects of E-1020. Saline and vehicle were infused into the left main coronary artery at a rate of 2 ml/min. The dose of intracoronary E-1020 increased from 2.5 to 5.0 and 7.5 μg/min. The inotropic effect of E-1020 was defined as the change in the slope of the end-systolic pressure-volume relationship (Emax), which was independent of afterload and preload. Emaxsignificantly increased at infusion rates of 7.5 μg/min from control. Peak + dP dt increased at an infusion rate of 5.0 μg/min or higher, while left-ventricular end-diastolic pressure (LVEDP) decreased significantly at a rate of 5.0 and 7.5 μg/min. Intracoronary infusion of E-1020 at a rate of 2.5 μg/min produced a plasma concentration of 20 ng/ml, which was identical to the minimum effective plasma concentration seen in previous study by intra venous infusion. However, at a plasma concentration of 20 ng/ml, E-1020 has more vasodilating effects than inotropic effects. Clinically, E-1020 appears to have a positive inotropic effect that depends on the extent of myocardial perfusion.
影响因子：
37.8
作者：
LUDMER, PL;WRIGHT, RF;COLUCCI, WS
通讯作者：
COLUCCI, WS
正性肌力药物和血管扩张剂治疗对充血性心肌病患者舒张特性的不同影响。
影响因子：
37.8
作者：
Carroll,JD;Lang,RM;Neumann,AL;Borow,KM;Rajfer,SI
通讯作者：
Rajfer,SI