Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST Elevation Acute Coronary Syndrome
Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST Elevation Acute Coronary Syndrome
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DOI：
10.1155/2020/1860268
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发表时间：
2020-08-17
影响因子：
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通讯作者：
Yan, Gaoliang
中科院分区：
文献类型：
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作者：
Li, Mingkang;Tang, Chengchun;Yan, Gaoliang
先前的研究表明，纤维蛋白原与白蛋白比值（FAR）被视为一种新型炎症和血栓生物标志物，是冠状动脉疾病（CAD）的危险因素。在本研究中，我们试图评估首次植入药物洗脱支架（DES）的非ST段抬高型急性冠状动脉综合征（NSTE-ACS）患者的FAR与CAD严重程度、长期预后之间的关系。本研究共招募了2017年1月至2018年12月期间首次植入DES的连续1138例NSTE-ACS患者。根据 FAR 水平将患者分为三组（第 1 组：10.481%）。使用 Gensini 评分 (GS) 评估 CAD 的严重程度。终点是主要不良心血管事件（MACE），包括全因死亡率、心肌再梗塞和靶血管血运重建（TVR）。通过Spearman等级相关系数分析，FAR与GS呈正相关（r=0.170，P
Previous studies showed that fibrinogen-to-albumin ratio (FAR) regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). In this study, we sought to evaluate the relationship between FAR and severity of CAD, long-term prognosis in non-ST elevation acute coronary syndrome (NSTE-ACS) patients firstly implanted with drug-eluting stent (DES). A total of 1138 consecutive NSTE-ACS patients firstly implanted with DES from January 2017 to December 2018 were recruited in this study. Patients were divided into tertiles according to FAR levels (Group 1: 10.481%). The severity of CAD was evaluated using the Gensini Score (GS). The endpoints were major adverse cardiovascular events (MACE), including all-cause mortality, myocardial reinfarction, and target vessel revascularization (TVR). Positive correlation was detected by Spearman's rank correlation coefficient analysis between FAR and GS (r=0.170,P